{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:25:31Z","timestamp":1791156331206,"version":"4.1.0"},"reference-count":21,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:p> Pulmonary gas exchange and acid-base state were compared in nine Danish lowlanders (L) acclimatized to 5,260 m for 9 wk and seven native Bolivian residents (N) of La Paz (altitude 3,600\u20134,100 m) brought acutely to this altitude. We evaluated normalcy of arterial pH and assessed pulmonary gas exchange and acid-base balance at rest and during peak exercise when breathing room air and 55% O<jats:sub>2<\/jats:sub>. Despite 9 wk at 5,260 m and considerable renal bicarbonate excretion (arterial plasma HCO<jats:sub>3<\/jats:sub> <jats:sup>\u2212<\/jats:sup> concentration = 15.1 meq\/l), resting arterial pH in L was 7.48 \u00b1 0.007 (significantly greater than 7.40). On the other hand, arterial pH in N was only 7.43 \u00b1 0.004 (despite arterial O<jats:sub>2<\/jats:sub> saturation of 77%) after ascent from 3,600\u20134,100 to 5,260 m in 2 h. Maximal power output was similar in the two groups breathing air, whereas on 55% O<jats:sub>2<\/jats:sub>only L showed a significant increase. During exercise in air, arterial Pco <jats:sub>2<\/jats:sub> was 8 Torr lower in L than in N ( P &lt; 0.001), yet Po <jats:sub>2<\/jats:sub> was the same such that, at maximal O<jats:sub>2<\/jats:sub> uptake,alveolar-arterial Po <jats:sub>2<\/jats:sub> difference was lower in N (5.3 \u00b1 1.3 Torr) than in L (10.5 \u00b1 0.8 Torr), P = 0.004. Calculated O<jats:sub>2<\/jats:sub> diffusing capacity was 40% higher in N than in L and, if referenced to maximal hyperoxic work, capacity was 73% greater in N. Buffering of lactic acid was greater in N, with 20% less increase in base deficit per millimole per liter rise in lactate. These data show in L persistent alkalosis even after 9 wk at 5,260 m. In N, the data show 1) insignificant reduction in exercise capacity when breathing air at 5,260 m compared with breathing 55% O<jats:sub>2<\/jats:sub>; 2) very little ventilatory response to acute hypoxemia (judged by arterial pH and arterial Pco <jats:sub>2<\/jats:sub> responses to hyperoxia); 3) during exercise, greater pulmonary diffusing capacity than in L, allowing maintenance of arterial Po <jats:sub>2<\/jats:sub>despite lower ventilation; and 4) better buffering of lactic acid. These results support and extend similar observations concerning adaptation in lung function in these and other high-altitude native groups previously performed at much lower altitudes. <\/jats:p>","DOI":"10.1152\/japplphysiol.00093.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:40:08Z","timestamp":1425415208000},"page":"1393-1400","source":"Crossref","is-referenced-by-count":96,"title":["Pulmonary gas exchange and acid-base state at 5,260 m  in high-altitude Bolivians and acclimatized lowlanders"],"prefix":"10.1152","volume":"92","author":[{"given":"Peter D.","family":"Wagner","sequence":"first","affiliation":[{"name":"Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Araoz","sequence":"additional","affiliation":[{"name":"Instituto Boliviano de Biologia de Altura, Bolivia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Boushel","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Centre, Copenhagen, Denmark 2200;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A. L.","family":"Calbet","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Centre, Copenhagen, Denmark 2200;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Jessen","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Centre, Copenhagen, Denmark 2200;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"R\u00e5degran","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Centre, Copenhagen, Denmark 2200;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Spielvogel","sequence":"additional","affiliation":[{"name":"Instituto Boliviano de Biologia de Altura, Bolivia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"S\u00f8ndegaard","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Centre, Copenhagen, Denmark 2200;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrieth","family":"Wagner","sequence":"additional","affiliation":[{"name":"Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Saltin","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Centre, Copenhagen, Denmark 2200;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015794"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.4.1506"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/hc4001.097040"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107497"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1970.29.1.71"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(71)90065-X"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.5.1868"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.2.685"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.51.5.1357"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(81)90121-3"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(83)90023-3"},{"key":"B13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1152\/ajplegacy.1949.157.3.445","volume":"157","author":"Rahn H","year":"1949","journal-title":"Am J Physiol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1997.574342000.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.1310020609"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.4.1309"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(78)90030-0"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.6.2348"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1972.33.1.62"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(80)90100-0"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.1.303"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(95)00041-0"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00093.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T19:28:44Z","timestamp":1567970924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00093.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,1]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4,1]]}},"alternative-id":["10.1152\/japplphysiol.00093.2001"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00093.2001","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,1]]}}}