{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:24:05Z","timestamp":1777699445923,"version":"3.51.4"},"reference-count":42,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2015,2,15]]},"abstract":"<jats:p>Cardiovascular biomarkers provide independent prognostic information in the assessment of mortality and cardiovascular complications. However, little is known about possible interactions between these biomarkers. In the present study, we evaluated the influence of B-type natriuretic peptide (BNP) on midregional-proadrenomedullin (MR-proADM), C-terminal-proendothelin-1 (CT-proET-1), growth differentiation factor-15 (GDF-15), midregional-proatrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin in healthy volunteers. Ten healthy male subjects (mean age 24 yr) participating in a randomized, placebo-controlled, single-blinded crossover study received placebo or 3.0 pmol\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>human BNP 32 during a continuous infusion lasting for 4 h. Effects of BNP on other cardiovascular biomarkers were assessed. BNP did not change concentrations of MR-proADM, copeptin, CT-proET1, GDF-15, or procalcitonin. In contrast, MR-proANP was significantly decreased during BNP infusion. BNP as an established cardiovascular biomarker did not affect plasma concentrations of other cardiovascular biomarkers in a model of healthy volunteers.<\/jats:p>","DOI":"10.1152\/japplphysiol.00101.2014","type":"journal-article","created":{"date-parts":[[2014,12,25]],"date-time":"2014-12-25T03:29:13Z","timestamp":1419478153000},"page":"395-399","source":"Crossref","is-referenced-by-count":3,"title":["Effects of B-type natriuretic peptide on cardiovascular biomarkers in healthy volunteers"],"prefix":"10.1152","volume":"118","author":[{"given":"M.","family":"Resl","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria;"},{"name":"Department of Internal Medicine, Konventhospital Barmherzige Brueder, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Vila","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and 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