{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:14:00Z","timestamp":1780373640489,"version":"3.54.1"},"reference-count":58,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100010090","name":"Women and Children's Health Research Institute","doi-asserted-by":"crossref","award":["R ES0018745"],"award-info":[{"award-number":["R ES0018745"]}],"id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["RGPIN-2014-06637"],"award-info":[{"award-number":["RGPIN-2014-06637"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Alberta Human Performance and Scholarship Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2015,9,1]]},"abstract":"<jats:p>Muscle sympathetic nerve activity is increased during normotensive pregnancy while mean arterial pressure is maintained or reduced, suggesting baroreflex resetting. We hypothesized spontaneous sympathetic baroreflex gain would be reduced in normotensive pregnant women relative to nonpregnant matched controls. Integrated muscle sympathetic burst incidence and total sympathetic activity (microneurography), blood pressure (Finometer), and R-R interval (ECG) were assessed at rest in 11 pregnant women (33 \u00b1 1 wk gestation, 31 \u00b1 1 yr, prepregnancy BMI: 23.5 \u00b1 0.9 kg\/m<jats:sup>2<\/jats:sup>) and 11 nonpregnant controls (29 \u00b1 1 yr; BMI: 25.2 \u00b1 1.7 kg\/m<jats:sup>2<\/jats:sup>). Pregnant women had elevated baseline sympathetic burst incidence (43 \u00b1 2 vs. 33 \u00b1 2 bursts\/100 heart beats, P = 0.01) and total sympathetic activity (1,811 \u00b1 148 vs. 1,140 \u00b1 55 au, P &lt; 0.01) relative to controls. Both mean (88 \u00b1 3 vs. 91 \u00b1 2 mmHg, P = 0.4) and diastolic (DBP) (72 \u00b1 3 vs. 73 \u00b1 2 mmHg, P = 0.7) pressures were similar between pregnant and nonpregnant women, respectively, indicating an upward resetting of the baroreflex set point with pregnancy. Baroreflex gain, calculated as the linear relationship between sympathetic burst incidence and DBP, was reduced in pregnant women relative to controls (\u22123.7 \u00b1 0.5 vs. \u22125.4 \u00b1 0.5 bursts\u00b7100 heart beats<jats:sup>\u22121<\/jats:sup>\u00b7mmHg<jats:sup>\u22121<\/jats:sup>, P = 0.03), as was baroreflex gain calculated with total sympathetic activity (\u2212294 \u00b1 24 vs. \u2212210 \u00b1 24 au\u00b7100 heart beats<jats:sup>\u22121<\/jats:sup>\u00b7mmHg<jats:sup>\u22121<\/jats:sup>; P = 0.03). Cardiovagal baroreflex gain (sequence method) was not different between nonpregnant controls and pregnant women (49 \u00b1 8 vs. 36 \u00b1 8 ms\/mmHg; P = 0.2). However, sympathetic (burst incidence) and cardiovagal gains were negatively correlated in pregnant women ( R = \u22120.7; P = 0.02). Together, these data indicate that the influence of the sympathetic nervous system over arterial blood pressure is reduced in normotensive pregnancy, in terms of both long-term and beat-to-beat regulation of arterial pressure, likely through a baroreceptor-dependent mechanism.<\/jats:p>","DOI":"10.1152\/japplphysiol.00131.2015","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T20:12:08Z","timestamp":1435954328000},"page":"468-474","source":"Crossref","is-referenced-by-count":47,"title":["Sympathetic baroreflex gain in normotensive pregnant women"],"prefix":"10.1152","volume":"119","author":[{"given":"Charlotte W.","family":"Usselman","sequence":"first","affiliation":[{"name":"Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory, Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada;"},{"name":"Alberta Diabetes Institute,"},{"name":"Women and Children's Health Research Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J.","family":"Skow","sequence":"additional","affiliation":[{"name":"Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory, Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada;"},{"name":"Alberta Diabetes Institute,"},{"name":"Women and Children's Health Research Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany A.","family":"Matenchuk","sequence":"additional","affiliation":[{"name":"Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory, Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada;"},{"name":"Alberta Diabetes Institute,"},{"name":"Women and Children's Health Research Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha S.","family":"Chari","sequence":"additional","affiliation":[{"name":"Department of 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