{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:22:11Z","timestamp":1791400931699,"version":"4.3.3"},"reference-count":45,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p>Motor incoordination is frequently used as a behavioral index of intoxication by drugs that depress the central nervous system. Two tasks that have been used to assay incoordination in mice, the balance beam and the grid test, were evaluated to optimize aspects of apparatus and testing procedures for studying genetic differences. Mice of eight inbred strains were given one of several doses of ethanol or saline and tested for intoxication. Strains differed in sensitivity to ethanol in both tests, indicating a significant influence of genotype on ethanol sensitivity. For the balance beam, the width of the beam affected the strain sensitivity pattern, and only the widest beam worked well at all doses. For the grid test, both ethanol dose and the time after drug injection affected strains differentially. Although the behavioral sign of intoxication recorded for both tests was a foot-slip error, the correlations of strain means for ethanol sensitivity across the two tasks were generally not significant. This suggests that the genes influencing ethanol sensitivity in the two tasks are mostly different. These results make clear that a single set of task parameters is insufficient to characterize genetic influences on behavior. Several other issues affect the interpretation of data using these tests.<\/jats:p>","DOI":"10.1152\/japplphysiol.00132.2003","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:46:54Z","timestamp":1425415614000},"page":"1338-1351","source":"Crossref","is-referenced-by-count":67,"title":["Genotypic differences in ethanol sensitivity in two tests of motor incoordination"],"prefix":"10.1152","volume":"95","author":[{"given":"John C.","family":"Crabbe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Metten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P.","family":"Schlumbohm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy J.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Wahlsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03186-3"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03201278"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00426638"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.114.2.401"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00231-5"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.97.2.280"},{"key":"REF8","unstructured":"Crabbe JC, Cotnam CJ, Cameron AJ, Schlumbohm JP, Rhodes JS, Melten P, and Wahlsten D.Strain differences in three measures of ethanol intoxication in mice: the screen, dowel, and grip strength tests.Genes Brain Behav.In press."},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.108.1.186"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1982.tb05007.x"},{"key":"REF11","doi-asserted-by":"publisher","DOI":"10.1037\/h0077898"},{"key":"REF12","unstructured":"Crabbe JC, Phillips TJ, Gallaher EJ, Crawshaw LI, and Mitchell SR.Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD\/Ty recombinant inbred mice: genetic correlations and quantitative trait loci.J Pharmacol Exp Ther277: 624-632, 1996."},{"key":"REF13","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5420.1670"},{"key":"REF14","doi-asserted-by":"crossref","unstructured":"Crabbe JC, Young ER, and Kosobud A.Genetic correlations with ethanol withdrawal severity.Pharmacol Biochem Behav18,Suppl1: 541-547, 1983.","DOI":"10.1016\/0091-3057(83)90233-2"},{"key":"REF15","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050327"},{"key":"REF16","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)00107-8"},{"key":"REF17","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(83)90819-6"},{"key":"REF18","doi-asserted-by":"crossref","unstructured":"Gallaher EJ, Jones GE, Belknap JK, and Crabbe JC.Identification of genetic markers for initial sensitivity and rapid tolerance to ethanol-induced ataxia using quantitative trait locus analysis in BXD recombinant inbred mice.J Pharmacol Exp Ther277: 604-612, 1996.","DOI":"10.1016\/S0022-3565(25)12913-3"},{"key":"REF19","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02250-6"},{"key":"REF20","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.1998.3843"},{"key":"REF21","unstructured":"Hampton TG, Kale A, Gladstone K, Bridges J, Costa ACS, and Amende I.How to characterize gait dynamics in mouse models of neuromuscular diseases. 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