{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:23:09Z","timestamp":1787509389602,"version":"build-2736575974"},"reference-count":45,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p>\n                    Electrical stimulation of the cerebellar fastigial nucleus (FN) evokes hyperventilation and hypertension responses that are similar to those induced by stimulation of the medial region of the vestibular nucleus (VN\n                    <jats:sub>M<\/jats:sub>\n                    ). Because there are mutual projections between these two nuclei morphologically, we hypothesized that the FN-mediated cardiorespiratory responses were related to the integrity of the VN\n                    <jats:sub>M<\/jats:sub>\n                    . Experiments were conducted on 21 anesthetized, tracheotomized, and spontaneously breathing rats. Electrical stimulation (\u223c10 s) of the FN was used to evoke cardiorespiratory responses, and the same stimulus was repeated 30\u201345 min after bilateral lesions of the VN\n                    <jats:sub>M<\/jats:sub>\n                    by local microinjection of ibotenic acid (100 mM, 100 nl). We found that FN stimulation-induced hyperventilation and hypertension were attenuated significantly by the lesions. The role of the VN\n                    <jats:sub>M<\/jats:sub>\n                    in the ventilatory responses to chemical challenges was subsequently defined. The animals were exposed to hypercapnia (10% CO\n                    <jats:sub>2<\/jats:sub>\n                    ) and hypoxia (10% O\n                    <jats:sub>2<\/jats:sub>\n                    ) for 1\u20132 min randomly before and after VN\n                    <jats:sub>M<\/jats:sub>\n                    lesions. The results showed that VN\n                    <jats:sub>M<\/jats:sub>\n                    lesions significantly attenuated the cardiorespiratory responses to hypercapnia but not to hypoxia, with little effect on baseline respiratory variables. These findings suggest that the VN\n                    <jats:sub>M<\/jats:sub>\n                    is required for full expression of the cardiorespiratory responses to electrical stimulation of the FN as well as to hypercapnia. However, neurons within the VN\n                    <jats:sub>M<\/jats:sub>\n                    do not appear to be critical for maintaining eupneic breathing and the cardiorespiratory responses to hypoxia.\n                  <\/jats:p>","DOI":"10.1152\/japplphysiol.00134.2004","type":"journal-article","created":{"date-parts":[[2004,8,26]],"date-time":"2004-08-26T20:38:41Z","timestamp":1093552721000},"page":"835-842","source":"Crossref","is-referenced-by-count":26,"title":["Medial vestibular nucleus mediates the cardiorespiratory responses to fastigial nuclear activation and hypercapnia"],"prefix":"10.1152","volume":"97","author":[{"given":"Joseph P.","family":"Hernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald T.","family":"Frazier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050170055017"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(82)90004-4"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901140307"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901110102"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01969-3"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-199911000-00002"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.5.2076"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199204000-00019"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200008000-00004"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00317-8"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(95)90019-5"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018556"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Ito M\n                      , Udo M, Mano N, and Kawai N.\n                      Synaptic action of the fastigiobulbar impulses upon neurones in the medullary reticular formation and vestibular nuclei.\n                      Exp Brain Res\n                      11\n                      : 29\u201347, 1970.","DOI":"10.1007\/BF00234200"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1986.250.3.R418"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(89)90092-1"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(88)90011-1"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00568.2001"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02370-8"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903020211"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688177"},{"key":"R21","unstructured":"Omori O\n                      , Umetani T, and Sugioka K.\n                      Projections from the subdivisions of the fastigial nucleus to the vestibular complex and the prepositus hypoglossal nucleus in the albino rat: an anterograde tracing study using biocytin.\n                      Kobe J Med Sci\n                      43\n                      : 37\u201354, 1997."},{"key":"R22","unstructured":"Paxios G\n                      and Watson C.\n                      The Rat Brain in Stereotaxic Coordinates\n                      . 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