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Matrix metalloproteinases (MMPs) are enzymes that digest collagen and other structural molecules, which are synthesized and excreted by fibroblasts. MMPs are required for baseline ECM homeostasis, but disruption of MMP regulation due to injury or disease can alter the normal ECM architecture and prevent proper force transmission. Chronic injuries and diseases of muscles and tendons can be severely debilitating, and current therapeutic modalities to enhance healing are quite limited. This review will discuss the mechanobiology of MMPs, and the potential use of MMP inhibitors to improve the treatment of injured and diseased skeletal muscle and tendon tissue.<\/jats:p>","DOI":"10.1152\/japplphysiol.00137.2013","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T23:53:26Z","timestamp":1367538806000},"page":"884-891","source":"Crossref","is-referenced-by-count":100,"title":["MMP inhibition as a potential method to augment the healing of skeletal muscle and tendon extracellular matrix"],"prefix":"10.1152","volume":"115","author":[{"given":"Max E.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Gumucio","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan;"},{"name":"Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer B.","family":"Sugg","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan;"},{"name":"Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan; and"},{"name":"Department of Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asheesh","family":"Bedi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Mendias","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan;"},{"name":"Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.07.023"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-008-9565-1"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0260-1"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00075-4"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20347"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509347366"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2009.07.010"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(02)00138-1"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nm1630"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000144166.66737.3a"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/b103817"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00057.2012"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200312071"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(96)00015-0"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2009.01.012"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2011.10.020"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(99)00515-0"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07688.x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000138251.07040.51"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1177\/0363546506297539"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1042\/BST20110720"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22259"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.2.534"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.127639"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-225599"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2011.08.002"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1177\/0363546505274714"},{"key":"B28","unstructured":"J\u00f3za LG, Kannus P.\n                      Human Tendons: Anatomy, Physiology, and Pathology\n                      . 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