{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:41:56Z","timestamp":1778172116451,"version":"3.51.4"},"reference-count":62,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100007197","name":"HHS | U.S. Public Health Service","doi-asserted-by":"publisher","award":["ES026529"],"award-info":[{"award-number":["ES026529"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"HHS | U.S. Public Health Service","doi-asserted-by":"publisher","award":["UL1TR001998"],"award-info":[{"award-number":["UL1TR001998"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","award":["MISP 100107"],"award-info":[{"award-number":["MISP 100107"]}],"id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST-110-2917-I-038-001"],"award-info":[{"award-number":["MOST-110-2917-I-038-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST-111-2917-I-038-001"],"award-info":[{"award-number":["MOST-111-2917-I-038-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p> Extracellular adenosine triphosphate (ATP) is a contributing factor and signaling molecule of airway inflammation. This study demonstrated for the first time that the ATP release in the lung was markedly elevated after acute inhalation challenges of three common industrial air pollutants; the order of the response magnitude was chlorine &gt; sulfur dioxide &gt; ammonia. These findings provided new information and improved our understanding of the adverse pulmonary effects caused by accidental inhalation exposures to these irritant gases. <\/jats:p>","DOI":"10.1152\/japplphysiol.00137.2024","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T08:01:58Z","timestamp":1719475318000},"page":"581-590","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Release of ATP in the lung evoked by inhalation of irritant gases in rats"],"prefix":"10.1152","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7842-9761","authenticated-orcid":false,"given":"Nai-Ju","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Kentucky Medical Center, Lexington, Kentucky, United States"},{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueh-Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Kentucky Medical Center, Lexington, Kentucky, United States"},{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2319-2151","authenticated-orcid":false,"given":"Chun-Chun","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You Shuei","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell","family":"Zakeri","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Kentucky Medical Center, Lexington, Kentucky, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seonwook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Kentucky Medical Center, Lexington, Kentucky, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Khosravi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Kentucky Medical Center, Lexington, Kentucky, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8306-2845","authenticated-orcid":false,"given":"Lu-Yuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Kentucky Medical Center, Lexington, Kentucky, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2006"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-012-9304-9"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/s0005-2736(03)00210-4"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.260562"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-017-9599-7"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005389"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000613RRR"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90549.2008"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00450.2020"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nm1617"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00439-2019"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.04.019"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0493OC"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.06.045"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1177\/1753466619877960"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0359OC"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30471-0"},{"key":"B18","unstructured":"Department of Health and Human Services. Public Health Statement: Sulfur Dioxide (CAS#: 7446-09-5). Atlanta, GA: Agency For Toxic Substances And Disease Registry, 1998."},{"key":"B19","unstructured":"Department of Health and Human Services. Public Health Statement: Ammonia (CAS#: 7664-41-7). Atlanta, GA: Agency For Toxic Substances And Disease Registry, 2004."},{"key":"B20","unstructured":"Department of Health and Human Services. Public Health Statement: Chlorine (CAS#: 7782-50-5). Atlanta, GA: Agency For Toxic Substances And Disease Registry, 2010."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.4137\/EHI.S15671"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1136\/thx.37.2.118"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/BF00378381"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1979.119.4.555"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.2.556"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2017.1388087"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/s40557-014-0029-9"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1177\/003335490712200610"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90253-k"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1159\/000236340"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.1.8025752"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2174\/138945008784533543"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01367.2007"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.161042"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00491.2013"},{"key":"B36","volume-title":"StatPearls","author":"Morim A","year":"2024"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1513\/pats.201001-008SM"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2007.04.013"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00336.2011"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.02.041"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91517.2008"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.03.009"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1300"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205467"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00267.2006"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2002-0117OC"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03118.x"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32831da8d3"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.042028"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021142"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00091.2021"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0027715"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130020"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00444.2016"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1113\/JP279152"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.70"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041222"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000549"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000588"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01633"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.140207"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-015-9493-0"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00137.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T13:19:26Z","timestamp":1725801566000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00137.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9,1]]}},"alternative-id":["10.1152\/japplphysiol.00137.2024"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00137.2024","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,1]]},"assertion":[{"value":"2024-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}