{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:08:37Z","timestamp":1785157717038,"version":"3.55.0"},"reference-count":65,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG44615"],"award-info":[{"award-number":["AG44615"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG086136"],"award-info":[{"award-number":["AG086136"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>Aging selectively impacts the function of type IIx\/IIb fibers in the diaphragm muscle. We show that sarcopenia reduces maximum specific force, maximum shortening velocity, and peak power output, whereas endurance during repetitive contractions is preserved. These findings explain why higher force airway clearance behaviors decline with age, whereas fatigue-resistant breathing behavior remains resilient.<\/jats:p>","DOI":"10.1152\/japplphysiol.00148.2026","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T16:14:11Z","timestamp":1781280851000},"page":"194-204","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Aging slows maximum shortening velocity and reduces peak power output of rat diaphragm muscle"],"prefix":"10.1152","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3906-272X","authenticated-orcid":false,"given":"Genesis A.","family":"Hernandez-Vizcarrondo","sequence":"first","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-7042","authenticated-orcid":false,"given":"Matthew J.","family":"Fogarty","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-1877","authenticated-orcid":false,"given":"Humzah","family":"Abdulkader","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy C.","family":"Sieck","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5446-9208","authenticated-orcid":false,"given":"Carlos B.","family":"Mantilla","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3040-9424","authenticated-orcid":false,"given":"Gary C.","family":"Sieck","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(21)00499-8"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/physiologyonline.1991.6.6.260"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(21)00958-8"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00002.2018"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.6.2539"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.07.001"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c180012"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13786"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633725"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.5.9154857"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00064.2015"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00481.2018"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.1.8025746"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2013.06.001"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1113\/EP085703"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90134-1"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.2.620"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.6.2179"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00617.2002"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00618.2002"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.5.1894"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/s0305-0491(98)00005-4"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.68.1.174"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.3.1341"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1113\/EP087558"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.6.2215"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/54.11.b492"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1988.59.3.1055"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.5.1640"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1139\/y91-035"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.5.1416"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.12.017"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.6.2680"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2021.103780"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.1.380"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.123.4.823"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/BF01739810"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.2.493"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00090.2022"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.2.695"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00061.2019"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00644.2019"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.727585"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15587"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1378\/chest.82.6.761"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmod.2019.10.002"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(83)90015-4"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00868.2017"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.4.1445"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91247.2008"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00172.2010"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.4.1145"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.4.1196"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00862.2002"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2023.104180"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050088"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2023.104092"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-026-02226-7"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197709000-00010"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510x(77)90069-7"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.2535\/ofaj1936.73.4_171"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028090"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e318181d5b5"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.2.8306041"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1186\/cc4926"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00148.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:50:18Z","timestamp":1783608618000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00148.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1152\/japplphysiol.00148.2026"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00148.2026","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}