{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T11:42:18Z","timestamp":1742384538305},"reference-count":27,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p> This study tested the hypothesis that the extent of the decrement in V\u0307o<jats:sub>2max<\/jats:sub> and the respiratory response seen during maximal exercise in moderate hypobaric hypoxia (H; simulated 2,500 m) is affected by the hypoxia ventilatory and hypercapnia ventilatory responses (HVR and HCVR, respectively). Twenty men (5 untrained subjects, 7 long distance runners, 8 middle distance runners) performed incremental exhaustive running tests in H and normobaric normoxia (N) condition. During the running test, V\u0307o<jats:sub>2<\/jats:sub>, pulmonary ventilation (V\u0307e) and arterial oxyhemoglobin saturation (Sa<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>) were measured, and in two ventilatory response tests performed during N, a rebreathing method was used to evaluate HVR and HCVR. Mean HVR and HCVR were 0.36 \u00b1 0.04 and 2.11 \u00b1 0.2 l\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7mmHg<jats:sup>\u22121<\/jats:sup>, respectively. HVR correlated significantly with the percent decrements in V\u0307o<jats:sub>2max<\/jats:sub> (%dV\u0307o<jats:sub>2max<\/jats:sub>), Sa<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub> [%dSa<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub> = (N\u2212H)\u00b7N<jats:sup>\u22121<\/jats:sup>\u00b7100], and V\u0307e\/V\u0307o<jats:sub>2<\/jats:sub> seen during H condition. By contrast, HCVR did not correlate with any of the variables tested. The increment in maximal V\u0307e between H and N significantly correlated with %dV\u0307o<jats:sub>2max<\/jats:sub>. Our findings suggest that O<jats:sub>2<\/jats:sub> chemosensitivity plays a significant role in determining the level of exercise hyperventilation during moderate hypoxia; thus, a higher O<jats:sub>2<\/jats:sub> chemosensitivity was associated with a smaller drop in V\u0307o<jats:sub>2max<\/jats:sub> and Sa<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub> under those conditions. <\/jats:p>","DOI":"10.1152\/japplphysiol.00153.2007","type":"journal-article","created":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T01:09:56Z","timestamp":1185498596000},"page":"1221-1226","source":"Crossref","is-referenced-by-count":23,"title":["Relationship between resting ventilatory chemosensitivity and maximal oxygen uptake in moderate hypobaric hypoxia"],"prefix":"10.1152","volume":"103","author":[{"given":"Takeshi","family":"Ogawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nishiyasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00964122"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-003-0899-y"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1971.30.1.91"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00565.2001"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(98)00043-7"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199802000-00004"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.2.575"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.3.1119"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(95)00028-3"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.3.874"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-003-0902-7"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-972968"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.4.1486"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.45.4.557"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1080\/02640419308729961"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.2.500"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.6.1872"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.4.1407"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-005-1322-7"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1007\/BF02388629"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1111\/imj.1967.16.1.20"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Robergs RA, Quintana R, Parker DL, Frankel CC. 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