{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:50:48Z","timestamp":1773460248740,"version":"3.50.1"},"reference-count":64,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p> The purpose of this study was to examine the influence of acute plasma volume expansion (APVE) on oxygen uptake (V\u0307o<jats:sub>2<\/jats:sub>) kinetics, V\u0307o<jats:sub>2peak<\/jats:sub>, and time to exhaustion during severe-intensity exercise. Eight recreationally active men performed \u201cstep\u201d cycle ergometer exercise tests at a work rate requiring 70% of the difference between the gas-exchange threshold and V\u0307o<jats:sub>2max<\/jats:sub> on three occasions: twice as a \u201ccontrol\u201d (Con) and once after intravenous infusion of a plasma volume expander (Gelofusine; 7 ml\/kg body mass). Pulmonary gas exchange was measured breath by breath. APVE resulted in a significant reduction in hemoglobin concentration (preinfusion: 16.0 \u00b1 1.0 vs. postinfusion: 14.7 \u00b1 0.8 g\/dl; P &lt; 0.001) and hematocrit (preinfusion: 44 \u00b1 2 vs. postinfusion: 41 \u00b1 3%; P &lt; 0.01). Despite this reduction in arterial O<jats:sub>2<\/jats:sub> content, APVE had no effect on V\u0307o<jats:sub>2<\/jats:sub> kinetics (phase II time constant, Con: 33 \u00b1 15 vs. APVE: 34 \u00b1 12 s; P = 0.74), and actually resulted in an increased V\u0307o<jats:sub>2peak<\/jats:sub> (Con: 3.90 \u00b1 0.56 vs. APVE: 4.12 \u00b1 0.55 l\/min; P = 0.006) and time to exhaustion (Con: 365 \u00b1 58 vs. APVE: 424 \u00b1 64 s; P = 0.04). The maximum O<jats:sub>2<\/jats:sub> pulse was also enhanced by the treatment (Con: 21.3 \u00b1 3.4 vs. APVE: 22.7 \u00b1 3.4 ml\/beat; P = 0.04). In conclusion, APVE does not alter V\u0307o<jats:sub>2<\/jats:sub> kinetics but enhances V\u0307o<jats:sub>2peak<\/jats:sub> and exercise tolerance during high-intensity cycle exercise in young recreationally active subjects. <\/jats:p>","DOI":"10.1152\/japplphysiol.00154.2006","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T07:57:18Z","timestamp":1147420638000},"page":"707-714","source":"Crossref","is-referenced-by-count":30,"title":["Influence of acute plasma volume expansion on V\u0307<scp>o<\/scp><sub>2<\/sub> kinetics, V\u0307<scp>o<\/scp><sub>2peak<\/sub>, and performance during high-intensity cycle exercise"],"prefix":"10.1152","volume":"101","author":[{"given":"Nicolas J. A.","family":"Berger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain T.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daryl P.","family":"Wilkerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011975"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.3.R899"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.6.2099"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200001000-00012"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1973.34.1.128"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.6.2020"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01095.2004"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01217.2001"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.032805"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00840.2003"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1174-0"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199112000-00004"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Convertino VA. Heart rate and sweat rate responses associated with exercise-induced hypervolemia. Med Sci Sports Exerc 15: 77\u201382, 1983.","DOI":"10.1249\/00005768-198315010-00014"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1980.48.4.665"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.1.95"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1024774"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.37.2.247"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.40.3.379"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.6.2500"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-001-0748-y"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1139\/h99-006"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000049746.29175.3F"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.3.988"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.5.1944"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198706000-00003"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.5.2032"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199008000-00012"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.5.1573"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.2.609"},{"key":"R30","doi-asserted-by":"crossref","unstructured":"Hopper MK, Coggan AR, and Coyle EF. Exercise stroke volume relative to plasma-volume expansion. Med Sci Sports Exerc 64: 404\u2013408, 1988.","DOI":"10.1152\/jappl.1988.64.1.404"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.6.1886"},{"key":"R32","unstructured":"Hughson RL. Regulation of V\u0307o2 on-kinetics by O2 delivery. In: Oxygen Uptake Kinetics in Sport, Health and Medicine, edited by Jones AM and Poole DC. London: Routledge, p. 185\u2013211, 2005."},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.5.1962"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1139\/h95-014"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1007\/BF00429035"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.057711"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000177466.01232.7e"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.52.5.1186"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198406000-00010"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.5.1791"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.1.253"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199711000-00013"},{"key":"R43","doi-asserted-by":"crossref","unstructured":"Luetkemeier MJ and Thomas EL. Hypervolemia and cycling time trial performance. Med Sci Sports Exerc 26: 503\u2013509, 1994.","DOI":"10.1249\/00005768-199404000-00016"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.5.1622"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-78-1-67"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.4.1180"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.6.1914"},{"key":"R48","unstructured":"Poole DC, Barstow TJ, Gaesser GA, Willis WT, and Whipp BJ. V\u0307o2 slow component: physiological and functional significance. Med Sci Sports Exerc 26: 1354\u20131358, 1994."},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1080\/00140138808966766"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00932.2005"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00446.2002"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1974.54.1.75"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(89)90138-2"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.2.491"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.5.1942"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00532.2002"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199906000-00007"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.50.1.217"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.1042\/bst0300237"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1972.33.3.351"},{"key":"R61","unstructured":"Wilkerson DP, Berger NJ, and Jones AM. Influence of hyperoxia on pulmonary O2 uptake kinetics following the onset of exercise in humans. Respir Physiol Neurobiol. In press."},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.089920"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1996.sp003970"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.1007\/BF00376445"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00154.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T20:39:22Z","timestamp":1567975162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00154.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1152\/japplphysiol.00154.2006"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00154.2006","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}