{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:54:40Z","timestamp":1771883680569,"version":"3.50.1"},"reference-count":28,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>Since alterations in pulmonary hemodynamics may lead to airway hyperreactivity, the consequences of individual changes in pulmonary blood flow (Q\u0307p) and capillary pressure (Pc) on lung responsiveness were investigated. During maintenance of a steady-state Pc of 5, 10, or 15 mmHg ( groups 1\u20133), acute increases of Q\u0307p were generated in isolated, perfused rat lungs by simultaneous pulmonary arterial pressure elevation and venous pressure lowering. Conversely, at constant low ( groups 4 and 5) or high Q\u0307p ( groups 6 and 7), Pc was lowered or elevated by changing, in parallel, the pulmonary arterial and venous pressures. Pulmonary input impedance was measured under baseline conditions and during methacholine provocation (2\u201318 \u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>), whereas the pulmonary hemodynamics were altered in accordance with the group allocation. The airway resistance and constant-phase parenchymal model parameters were identified from the pulmonary input impedance spectra. Increases of Q\u0307p at constant Pc had no effect on the basal lung mechanics, whereas they enhanced the lung reactivity to methacholine, particularly when high Pc was maintained [peak airway resistance increases of 299 \u00b1 99% (SE) vs. 609 \u00b1 217% at Q\u0307p levels of 5 and 10 ml\/min, respectively, P &lt; 0.05]. In contrast, the change of Pc at constant Q\u0307p slightly deteriorated the basal parenchymal mechanics without affecting the lung responsiveness. These findings suggest that increases in Q\u0307p per se may lead to the development of airway hyperreactivity. This phenomenon may contribute to the airway susceptibility under conditions associated with simultaneous elevations in pulmonary vascular pressures and Q\u0307p, such as exercise-induced asthma and the situation in children with congenital heart diseases.<\/jats:p>","DOI":"10.1152\/japplphysiol.00157.2009","type":"journal-article","created":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T01:42:54Z","timestamp":1247190174000},"page":"780-786","source":"Crossref","is-referenced-by-count":8,"title":["Impact of elevated pulmonary blood flow and capillary pressure on lung responsiveness"],"prefix":"10.1152","volume":"107","author":[{"given":"Ferenc","family":"Pet\u00e1k","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor 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