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Although in rodent models this clearly arises by deletion of sarcomeres in series, the mechanism has not been proven conclusively in human chronic obstructive pulmonary disease. Unique characteristics of the adaptation in human diaphragms include shifts to more predominant slow, type I fibers, expressing slower myosin heavy chain isoforms, and type I and type II fiber atrophy. Although some laboratories report reductions in specific force, this may be accounted for by decreases in myosin heavy chain content as the muscles become more oxidative and more efficient. More recent findings have reported reductions in Ca<jats:sup>2+<\/jats:sup>sensitivity and reduced myofibrillar elastic recoil. In contrast, in rodent models of disease, there is no consistent evidence for loss of specific force, no consistent shift in fiber populations, and atrophy is predominantly seen only in fast, type IIX fibers. This review challenges the hypothesis that the adaptations in human diaphragm represent a form of dysfunction, secondary to systemic disease, and suggest that most findings can as well be attributed to adaptive processes of a complex muscle responding to unique alterations in its working environment.<\/jats:p>","DOI":"10.1152\/japplphysiol.00173.2009","type":"journal-article","created":{"date-parts":[[2009,4,10]],"date-time":"2009-04-10T01:46:33Z","timestamp":1239327993000},"page":"324-335","source":"Crossref","is-referenced-by-count":56,"title":["Respiratory muscle fiber remodeling in chronic hyperinflation: dysfunction or adaptation?"],"prefix":"10.1152","volume":"107","author":[{"given":"Thomas 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