{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:58:19Z","timestamp":1792151899517,"version":"4.4.0"},"reference-count":41,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>Aerobic exercise capacity is decreased at altitude because of combined decreases in arterial oxygenation and in cardiac output. Hypoxic pulmonary vasoconstriction could limit cardiac output in hypoxia. We tested the hypothesis that acetazolamide could improve exercise capacity at altitude by an increased arterial oxygenation and an inhibition of hypoxic pulmonary vasoconstriction. Resting and exercise pulmonary artery pressure (Ppa) and flow (Q) (Doppler echocardiography) and exercise capacity (cardiopulmonary exercise test) were determined at sea level, 10 days after arrival on the Bolivian altiplano, at Huayna Potosi (4,700 m), and again after the intake of 250 mg acetazolamide vs. a placebo three times a day for 24 h. Acetazolamide and placebo were administered double-blind and in a random sequence. Altitude shifted Ppa\/Q plots to higher pressures and decreased maximum O<jats:sub>2<\/jats:sub>consumption (V\u0307o<jats:sub>2max<\/jats:sub>). Acetazolamide had no effect on Ppa\/Q plots but increased arterial O<jats:sub>2<\/jats:sub>saturation at rest from 84 \u00b1 5 to 90 \u00b1 3% ( P &lt; 0.05) and at exercise from 79 \u00b1 6 to 83 \u00b1 4% ( P &lt; 0.05), and O<jats:sub>2<\/jats:sub>consumption at the anaerobic threshold (V-slope method) from 21 \u00b1 5 to 25 \u00b1 5 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7kg<jats:sup>\u22121<\/jats:sup>( P &lt; 0.01). However, acetazolamide did not affect V\u0307o<jats:sub>2max<\/jats:sub>(from 31 \u00b1 6 to 29 \u00b1 7 ml\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>), and the maximum respiratory exchange ratio decreased from 1.2 \u00b1 0.06 to 1.05 \u00b1 0.03 ( P &lt; 0.001). We conclude that acetazolamide does not affect maximum exercise capacity or pulmonary hemodynamics at high altitudes. Associated changes in the respiratory exchange ratio may be due to altered CO<jats:sub>2<\/jats:sub>production kinetics.<\/jats:p>","DOI":"10.1152\/japplphysiol.00180.2007","type":"journal-article","created":{"date-parts":[[2007,7,6]],"date-time":"2007-07-06T01:39:47Z","timestamp":1183685987000},"page":"1161-1165","source":"Crossref","is-referenced-by-count":44,"title":["Effects of acetazolamide on aerobic exercise capacity and pulmonary hemodynamics at high altitudes"],"prefix":"10.1152","volume":"103","author":[{"given":"Vitalie","family":"Faoro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Huez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Giltaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Pavelescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"van Osta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Moraine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Guenard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Beno\u00eet","family":"Martinot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Naeije","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13591-X"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1580\/1080-6032(2004)015[0032:IOHPVP]2.0.CO;2"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Bradwell AR, Dykes PW, Coote JH, Forster PJ, Miller JJ, Chesner I, Richardson NV.Effect of acetazolamide on exercise performance and muscle mass at high altitude.Lancet1: 1001\u20131005, 1986.","DOI":"10.1016\/S0140-6736(86)91272-9"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.4.1397"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.4.1402"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00565.2001"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-003-0031-1"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00148-1"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.3.H1126"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1042\/CS20050233"},{"key":"R11","unstructured":"Fulco CS, Rock PB, Cymerman A.Maximal and submaximal exercise performance at altitude.Aviat Space Environ Med69: 793\u2013801, 1998."},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050010"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00746.2001"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-3-200408030-00005"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.2.521"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198510000-00013"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01217.2003"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Hoehne C, Pickerodt PA, Francis RC, Boemke W, Swenson ER.Pulmonary vasodilation by acetazolamide during acute hypoxia is not related to carbonic anhydrase inhibition.Am J Physiol Lung Cell Mol Physiol292: L178\u2013L184, 2007.","DOI":"10.1152\/ajplung.00205.2006"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1977.43.6.959"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-003-0902-7"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.2.302"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00137605"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.16.2078"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417991"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1693-3"},{"key":"R26","doi-asserted-by":"crossref","unstructured":"Naeije R, Torbicki A.More on the noninvasive diagnosis pulmonary hypertension. Doppler echocardiography revisited.Eur Respir J8: 1445\u20131449, 1995.","DOI":"10.1183\/09031936.95.08091445"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.2.531"},{"key":"R28","unstructured":"Roach RC, B\u00e4rtsch P, Hackett PH, Oelz O.The Lake Louise acute mountain sickness scoring system. In:Hypoxia and Mountain Medicine, edited by Sutton JR, Houston CS, and Coates G. Burlington, VT: Queen City, 1993, p. 327\u2013330."},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-3-200408030-00016"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.2.713"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.6.1772"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00161.2006"},{"key":"R33","unstructured":"Stager JM, Tucker A, Cordain L, Engebretsen BJ, Brechue WF, Matulich CC.Normoxic and acute hypoxic exercise tolerance in man following acetazolamide.Med Sci Sports Exerc22: 178\u2013184, 1990."},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12061242"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(78)90018-X"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200608-1199OC"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(99)00101-2"},{"key":"R38","unstructured":"Wasserman K, Hansen JE, Sue DY, Whipp BJ.Principles of Exercise Testing and Interpretation(3rd ed.). Baltimore, MD: Lippincott Williams and Wilkins, 1999, p. 143\u2013164."},{"key":"R39","unstructured":"Winer BJ, Brown DR, Brown DR, Michels KM.Statistical Principles in Experimental Design(3rd ed.). New York: McGraw-Hill, 1991, p. 220\u2013283."},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00409.2001"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.4.657"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00180.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T21:41:41Z","timestamp":1683927701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00180.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1152\/japplphysiol.00180.2007"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00180.2007","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}