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This review will provide the reader with 1) an understanding of the basic physics of blood flow and the theories of muscle pump function, 2) a critical examination of evidence both for and against the contribution of the muscle pump or rapid vasodilatory mechanisms, and 3) an awareness of the limitations and impact of experimental models and exercise modes on the contribution of each of these mechanisms to the immediate exercise hyperemia. The inability to measure microvenular pressure continues to limit investigators to indirect assessments of the muscle pump vs. vasodilatory mechanism contributions to immediate exercise hyperemia in vivo. Future research directions should include examination of muscle-contraction-induced resistance vessel distortion as a trigger for rapid smooth muscle relaxation and further investigation into the exercise mode dependency of muscle pump vs. rapid vasodilatory contributions to immediate exercise hyperemia. <\/jats:p>","DOI":"10.1152\/japplphysiol.00185.2004","type":"journal-article","created":{"date-parts":[[2004,7,10]],"date-time":"2004-07-10T05:09:24Z","timestamp":1089436164000},"page":"739-747","source":"Crossref","is-referenced-by-count":166,"title":["Immediate exercise hyperemia: contributions of the muscle pump vs. rapid vasodilation"],"prefix":"10.1152","volume":"97","author":[{"given":"Michael E.","family":"Tschakovsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don D.","family":"Sheriff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.3109\/00016926209171754"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Anrep GV and von Saalfeld E. 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