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The experimental treatments were as follows: no fluid (NF), glycerol bolus (1 g\/kg body wt) followed by water (G), and water alone (W). Rehydration (3% body weight) was given over an 80-min period. After rehydration, subjects cycled (74% peak O<jats:sub>2<\/jats:sub> uptake) to exhaustion in a hot and wet (37\u00b0C and 48% relative humidity) environment. For G, plasma volume was expanded ( P &lt; 0.05) during rehydration and remained higher than W ( P &lt; 0.05) during exercise. Exercise time to exhaustion during G (33 \u00b1 4 min) was longer ( P &lt; 0.05) compared with both W (27 \u00b1 3 min) and NF (19 \u00b1 3 min). Cutaneous vascular conductance was significantly elevated ( P &lt; 0.05) during G, but G provided no other thermoregulatory or cardiovascular benefits compared with W and NF. Fluid-regulating hormones (vasopressin, aldosterone, atriopeptin, and plasma renin activity) decreased during rehydration and increased during exercise (except atriopeptin), but there were no differences between G and W. These data indicated that glycerol had little or no major effect on fluid-regulating factors during rehydration or exercise, and the improved exercise capacity in G was likely due to a greater plasma volume during exercise. <\/jats:p>","DOI":"10.1152\/japplphysiol.00187.2005","type":"journal-article","created":{"date-parts":[[2005,10,7]],"date-time":"2005-10-07T00:34:10Z","timestamp":1128645250000},"page":"442-450","source":"Crossref","is-referenced-by-count":43,"title":["Rehydration with glycerol: endocrine, cardiovascular, and thermoregulatory responses during exercise in the heat"],"prefix":"10.1152","volume":"100","author":[{"given":"Stavros A.","family":"Kavouras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence E.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl M.","family":"Maresh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas J.","family":"Casa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge A.","family":"Herrera-Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy P.","family":"Scheett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Stoppani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary W.","family":"Mack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(85)90140-9"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.11.3.315"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1080\/00913847.1986.11709011"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.6.2028"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00418516"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1963.tb17079.x"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199610000-00045"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.54.2.508"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.12.1.105"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1958.13.2.159"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.37.2.247"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.272.6.R1740"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.2.669"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.6.2069"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1007\/BF00423211"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1988.254.6.1-b"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.4.1229"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199206000-00007"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050623"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199808000-00013"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050550"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.6.2117"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00316-X"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417983"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.3.860"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.6.1858"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(93)90165-Y"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199008000-00010"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200301000-00023"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00956.2003"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1058-3"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1007\/BF00418464"},{"key":"R33","doi-asserted-by":"crossref","unstructured":"McKinley MJ and Johnson AK. 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