{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T09:12:55Z","timestamp":1753521175946,"version":"3.37.3"},"reference-count":60,"publisher":"American Physiological Society","issue":"3","funder":[{"name":"Ross Maclean Fellowship"},{"name":"Bill Guest FightMND Mid-Career Development Fellowship"},{"name":"Brazil Family Program for Neurology"},{"DOI":"10.13039\/501100001778","name":"Deakin University","doi-asserted-by":"publisher","award":["Alfred Deakin PostDoc Fellowship"],"award-info":[{"award-number":["Alfred Deakin PostDoc Fellowship"]}],"id":[{"id":"10.13039\/501100001778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015144","name":"Deakin University | Institute for Physical Activity and Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015144","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001543","name":"Neurological Foundation of New Zealand","doi-asserted-by":"publisher","award":["Philip Wrightson Fellowship"],"award-info":[{"award-number":["Philip Wrightson Fellowship"]}],"id":[{"id":"10.13039\/501100001543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian National Health and Medical Research Council","award":["1124005"],"award-info":[{"award-number":["1124005"]}]},{"name":"Onassis Foundation Greece"}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p> This is the first study to investigate the capacity of symptomatic rNLS8 mice, which develop ALS-reminiscent TDP-43 pathology and motor dysfunction, to perform exercise training. We demonstrate that despite the ALS-reminiscent aggressive disease progression characterizing the rNLS8 mouse model, rNLS8 mice are capable of performing mild-to-moderate endurance treadmill training for at least 3\u20134 wk. We demonstrate that exercise training induces several minor skeletal muscle adaptations without delaying disease progression in rNLS8 mice. <\/jats:p>","DOI":"10.1152\/japplphysiol.00192.2023","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T18:20:29Z","timestamp":1721067629000},"page":"728-745","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Exercise training induces mild skeletal muscle adaptations without altering disease progression in a TDP-43 mouse model"],"prefix":"10.1152","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6753-5945","authenticated-orcid":false,"given":"Stavroula","family":"Tsitkanou","sequence":"first","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, Victoria, Australia"},{"name":"Cachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angus","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, Victoria, Australia"},{"name":"School of Biological Sciences, Faculty of Science, University of Canterbury, Christchurch, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Abbott","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Foletta","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam K.","family":"Walker","sequence":"additional","affiliation":[{"name":"Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7323-9501","authenticated-orcid":false,"given":"Aaron P.","family":"Russell","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Della Gatta","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002014"},{"key":"B2","first-page":"71","volume":"59","author":"Laughlin MH","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-003-0833-3"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1996.tb00038.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.59.5.773"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh373"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826daf50"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103397"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-510x(99)00218-x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.08.009"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000264418.92308.a4"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-510x(01)00610-4"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00783"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-8966(03)00104-4"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10597"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.11.051"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20451"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.12.029"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20004"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.169748"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3791\/53257"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu605"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1457-16.2016"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0377-5"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1460-x"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-015-0338-x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105559"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.149286"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1159\/000338061"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1159\/000324159"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203065200"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.02.019"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26365"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5940748"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03337-5"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15422"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.02.006"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3791\/51846"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.085043"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3064"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/s0969-9961(03)00041-x"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.06.024"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1113\/EP089253"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-12-81"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2022.110912"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02036-9"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01239-x"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-022-01373-0"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.07.061"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00093.2011"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.128827"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.5.1900"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/sports9090127"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00272.2012"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13893"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53235-w"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2011.07.008"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-8966(97)00115-6"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21688"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.54.1.80"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00192.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T13:04:54Z","timestamp":1726232694000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00192.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9,1]]}},"alternative-id":["10.1152\/japplphysiol.00192.2023"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00192.2023","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"type":"print","value":"8750-7587"},{"type":"electronic","value":"1522-1601"}],"subject":[],"published":{"date-parts":[[2024,9,1]]},"assertion":[{"value":"2023-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}