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During the 7-wk remobilization, the CSA increased by 9% (to 4,943 mm<jats:sup>2<\/jats:sup>) and strength by 37% (to 176 Nm). Achilles tendon CSA did not change significantly during either immobilization or remobilization. Local collagen turnover was measured as the peritendinous concentrations of NH<jats:sub>2<\/jats:sub>-terminal propeptide of type I collagen (PINP) and COOH-terminal telopeptide region of type I collagen (ICTP), markers thought to be indexes of type I collagen synthesis and degradation, respectively. Both markers were increased (PINP: 257 vs. 56 ng\/ml; ICTP: 9.8 vs. 2.1 \u03bcg\/l) in the immobilized leg compared with the control leg after the 7 wk of immobilization, and levels decreased again in the immobilized leg during the recovery period (PINP: 103 vs. 44 ng\/ml; ICTP: 4.2 vs. 1.9 \u03bcg\/l). A significant reduction in calf muscle CSA and strength was found in relation to 7 wk of immobilization. Immobilization increased both collagen synthesis and degradation in tendon near tissue. However, it cannot be excluded that the facture of the ankle in close proximity could have affected these data. Remobilization increased muscle size and strength and tendon synthesis and degradation decreased to baseline levels. These dynamic changes in tendon connective tissue turnover were not associated with macroscopic changes in tendon size.<\/jats:p>","DOI":"10.1152\/japplphysiol.00201.2008","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T00:54:31Z","timestamp":1207875271000},"page":"420-426","source":"Crossref","is-referenced-by-count":37,"title":["Effects of long-term immobilization and recovery on human triceps surae and collagen turnover in the Achilles tendon in patients with healing ankle fracture"],"prefix":"10.1152","volume":"105","author":[{"given":"Britt","family":"Christensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Dyrberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Aagaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Enehjelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Krogsgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kj\u00e6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Langberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.142828"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-1383(87)90286-5"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.5.859"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.5.1687"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.4.1493"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00403.2003"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050247"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.1997.tb00121.x"},{"key":"R9","unstructured":"Karpakka J, Palokangas H, Virtanen P, Savolainen J, Kovanen V, Takala TES.The effects of immobilization on the biosynthesis and quality of achilles tendon in rats. 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