{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:35:18Z","timestamp":1761676518937,"version":"3.37.3"},"reference-count":50,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000055","name":"National Institute of Deafness and Communication Disorders","doi-asserted-by":"crossref","award":["1R01DC011311"],"award-info":[{"award-number":["1R01DC011311"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Deafness and Communication Disorder","award":["1R01DC011311"],"award-info":[{"award-number":["1R01DC011311"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:p>Unilateral vocal fold paralysis (UVP) occurs related to recurrent laryngeal nerve (RLN) impairment associated with impaired swallowing, voice production, and breathing functions. The majority of UVP cases occur subsequent to surgical intervention with approximately 12\u201342% having no known cause for the disease (i.e., idiopathic). Approximately two-thirds of those with UVP exhibit left-sided injury with the average onset at \u226550 yr of age in those diagnosed as idiopathic. Given the association between the RLN and the subclavian and aortic arch vessels, we hypothesized that changes in vascular tissues would result in increased aortic compliance in patients with idiopathic left-sided UVP compared with those without UVP. Gated MRI data enabled aortic arch diameter measures normalized to blood pressure across the cardiac cycles to derive aortic arch compliance. Compliance was compared between individuals with left-sided idiopathic UVP and age- and sex-matched normal controls. Three-way factorial ANOVA test showed that aortic arch compliance ( P = 0.02) and aortic arch diameter change in one cardiac cycle ( P = 0.04) are significantly higher in patients with idiopathic left-sided UVP compared with the controls. As previously demonstrated by other literature, our finding confirmed that compliance decreases with age ( P &lt; 0.0001) in both healthy individuals and patients with idiopathic UVP. Future studies will investigate parameters of aortic compliance change as a potential contributor to the onset of left-sided UVP.<\/jats:p><jats:p>NEW &amp; NOTEWORTHY Unilateral vocal fold paralysis results from impaired function of the recurrent laryngeal nerve (RLN) impacting breathing, swallowing, and voice production. A large proportion of adults suffering from this disorder have an idiopathic etiology (i.e., unknown cause). The current study determined that individuals diagnosed with left-sided idiopathic vocal fold paralysis exhibited significantly greater compliance than age- and sex-matched controls. These seminal findings suggest a link between aortic arch compliance levels and RLN function.<\/jats:p>","DOI":"10.1152\/japplphysiol.00239.2017","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:10:26Z","timestamp":1495152626000},"page":"303-309","source":"Crossref","is-referenced-by-count":13,"title":["Aortic arch compliance and idiopathic unilateral vocal fold paralysis"],"prefix":"10.1152","volume":"123","author":[{"given":"Reza","family":"Behkam","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara E.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Arizona, Tucson, Arizona;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Bierhals","sequence":"additional","affiliation":[{"name":"Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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