{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:58:04Z","timestamp":1780343884275,"version":"3.54.1"},"reference-count":82,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["408124\/2021\u20100"],"award-info":[{"award-number":["408124\/2021\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303735\/2021-0"],"award-info":[{"award-number":["303735\/2021-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/20403-6"],"award-info":[{"award-number":["2018\/20403-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/02755-0"],"award-info":[{"award-number":["2023\/02755-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201026\/210.181\/2020"],"award-info":[{"award-number":["E\u201026\/210.181\/2020"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p> Radiotherapy is used to treat chest tumors, but may induce radiation-induced lung injury (RILI) in some patients. In the current RILI model, significant changes were observed in both irradiated and nonirradiated lungs. Increased right ventricle afterload and kidney morphological alterations were detected, suggesting vascular congestion. This study highlights the well-known impact of RILI on lungs but also emphasizes the often-overlooked effects on heart and kidneys in clinical practice. <\/jats:p>","DOI":"10.1152\/japplphysiol.00241.2025","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T18:21:31Z","timestamp":1759256491000},"page":"1050-1063","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrative physiological study of radiation-induced lung injury: effects on cardiac function and kidney integrity"],"prefix":"10.1152","volume":"139","author":[{"given":"Lucas Rodrigues de","family":"Moraes","sequence":"first","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maicon Luiz de","family":"Lima","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Pedro Abido","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0921-8068","authenticated-orcid":false,"given":"Nazareth de Novaes","family":"Rocha","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]},{"name":"Instituto Biom\u00e9dico, Universidade Federal Fluminense","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tula Celeste Wilmart","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Jorge Vianna","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara de Souza","family":"Roque","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6033-1353","authenticated-orcid":false,"given":"Giovanna","family":"Costa Ferreira Santos","sequence":"additional","affiliation":[{"name":"Escola T\u00e9cnica Estadual Oscar Ten\u00f3rio","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Pereira da","family":"Cruz","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Gonzaga","family":"Veras","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Ara\u00fajo","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Henrique Lima da","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Ferreira de Magalh\u00e3es","family":"Sacramento","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8763-3059","authenticated-orcid":false,"given":"Adriana Lopes da Silva","family":"Vilardo","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Luiza","family":"Capelozzi","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5364-7305","authenticated-orcid":false,"given":"Camila Machado","family":"Baldavira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6879-3973","authenticated-orcid":false,"given":"Sarah Aparecida dos Santos","family":"Alves","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9443-3648","authenticated-orcid":false,"given":"Fernanda Ferreira","family":"Cruz","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1412-7136","authenticated-orcid":false,"given":"Patricia Rieken Macedo","family":"Rocco","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-7753","authenticated-orcid":false,"given":"Celso","family":"Caruso-Neves","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-4805","authenticated-orcid":false,"given":"Sergio Augusto Lopes de","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3876-4730","authenticated-orcid":false,"given":"Lorenzo","family":"Ball","sequence":"additional","affiliation":[{"name":"Universidade de Genoa","place":["It\u00e1lia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-4949","authenticated-orcid":false,"given":"Pedro Leme","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.194"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21689"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.03.033"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-01376-4"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04682-5"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2024.07.152"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01570-2"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0094TR"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02595-z"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00877\/full"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.01.051"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2017.11.022"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.1.8111603"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.887109"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14807"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.1.250"},{"key":"B19","doi-asserted-by":"publisher","unstructured":"Moraes L, Santos CL, Santos RS, Cruz FF, Saddy F, Morales MM, Capelozzi VL, Silva PL, de Abreu MG, Garcia CS, Pelosi P, Rocco PR. effects of sigh during pressure control and pressure support ventilation in pulmonary and extrapulmonary mild acute lung injury. 18: 474, 2014. doi:10.1186\/s13054-014-0474-4. 25113136","DOI":"10.1186\/s13054-014-0474-4"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04950-y"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1982.126.5.788"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121988"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173438"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2024.07.009"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17204-5"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.001746"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2021.129950"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175521"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-016-0179-8"},{"key":"B30","first-page":"258","volume":"11","author":"Pereira RO","year":"2019","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1393372"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.585756"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract11030056"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.01.006"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02120-2017"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200346"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041393"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14960"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.160291"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19343-9"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1080\/095530000138538"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9628-x"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1159\/000524596"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.794324\/full"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-3-40"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rry067\/5088059"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-024-03254-9"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.931023"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.123188"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126443"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-0632-6"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31822f09d7"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1186\/cc12738"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1513\/pats.201203-023AW"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2020.105802"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0009-2017"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/cells13110889"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2014-0343OC"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03533-z"},{"key":"B60","first-page":"527","volume":"148","author":"Zhang HY","year":"1996","journal-title":"Am J Pathol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00037.2018"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2018.07.001"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1336102"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.5012"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055727"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00150"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00217.2009"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.20.4.3357"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018020224"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13118"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-024-07588-8"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-36124-1"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2019.04.001"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000664"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04020417"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1754"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209825"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021686"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.06.009"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00092\/full"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-67202012000100011"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2005.04.002"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00241.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:47:27Z","timestamp":1761054447000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00241.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":82,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10,1]]}},"alternative-id":["10.1152\/japplphysiol.00241.2025"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00241.2025","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"assertion":[{"value":"2025-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}