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We induced ventricular hypertrophy in seven mice by infusion of angiotensin II through a subcutaneous pump, with seven other mice serving as controls. DT-MRI of explanted hearts was performed at 3.0 Tesla. We used the primary eigenvector in each voxel to determine the three-dimensional orientation of aggregated myocytes in respect to their helical angles and their transmural courses (intruding angles). Compared with controls, the hypertrophic hearts showed significant increases in myocardial mass and the outer radius of the left ventricular chamber ( P &lt; 0.05). In both groups, a significant change was noted from positive intruding angles at the base to negative angles at the ventricular apex ( P &lt; 0.01). Compared with controls, the hypertrophied hearts had significantly larger intruding angles of the aggregated myocytes, notably in the apical and basal slices ( P &lt; 0.001). In both groups, the helical angles were greatest in midventricular sections, albeit with significantly smaller angles in the mice with hypertrophied myocardium ( P &lt; 0.01). The use of DT-MRI revealed significant differences in helix and intruding angles of the myocytes in the mice with hypertrophied myocardium.<\/jats:p>","DOI":"10.1152\/japplphysiol.00275.2009","type":"journal-article","created":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T01:42:02Z","timestamp":1248399722000},"page":"921-927","source":"Crossref","is-referenced-by-count":20,"title":["Three-dimensional alignment of the aggregated myocytes in the normal and hypertrophic murine heart"],"prefix":"10.1152","volume":"107","author":[{"given":"Boris","family":"Schmitt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsiaryna","family":"Fedarava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Falkenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Rothaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narendra K.","family":"Bodhey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"Reischauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Kozerke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Schnackenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Westermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul P.","family":"Lunkenheimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Titus","family":"Kuehne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Anderson RH, Ho SY, Sanchez-Quintana D, Redmann K, Lunkenheimer PP.Heuristic problems in defining the three-dimensional arrangement of the ventricular myocytes.Anat Rec A Discov Mol Cell Evol Biol288: 579\u2013586, 2006.","DOI":"10.1002\/ar.a.20330"},{"key":"R2","unstructured":"Benson AP, Gilbert SH, Bernus O, Ries ME, Ainscough JF, Ball SG, Holden AV.0.1 mm cubic voxel reconstruction of transgenic hypertrophic mouse heart structure using diffusion tensor magnetic resonance imaging.Proc Physiol Soc11: 2008."},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(94)90266-6"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00041.2005"},{"key":"R5","unstructured":"Cheng A, Nguyen TC, Malinowski M, Liang D, Daughters GT, Ingels NB Jr, Miller DC.Undersized mitral annuloplasty inhibits left ventricular basal wall thickening but does not affect equatorial wall cardiac strains.J Heart Valve Dis16: 349\u2013358, 2007."},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00968.2001"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.32.2.301"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.45.3.248"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.56.3.226"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20622"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Ingels NBJr.Myocardial fiber architecture and left ventricular function.Technol Health Care5: 45\u201352, 1997.","DOI":"10.3233\/THC-1997-51-205"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20191"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1370\/afm.141"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-4825(02)00085-9"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Lunkenheimer PP, Redmann K, Dietl KH, Cryer C, Richter KD, Whimster WF, Niederer P.The heart's fibre alignment assessed by comparing two digitizing systems. 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