{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:44:07Z","timestamp":1783028647836,"version":"3.54.6"},"reference-count":36,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100005416","name":"Norwegian Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:p> Rewarming from accidental hypothermia is associated with cardiovascular dysfunction that complicates rewarming and contributes to a high mortality rate. We investigated autonomic cardiovascular control, as well as the separate effects of cooling, hypothermia, and rewarming on hemodynamic function, aiming to provide knowledge of the pathophysiology causing such complications in these patients. A rat model designed for circulatory studies during cooling, hypothermia (15\u00b0C), and rewarming was used. Spectral analysis of diastolic arterial pressure and heart rate allowed assessment of the autonomic nervous system. Hemodynamic variables were monitored using a conductance catheter in the left ventricle and a pressure transducer connected to the left femoral artery. Sympathetic cardiovascular control was reduced after rewarming. Stroke volume increased during cooling but decreased during stable hypothermia and did not normalize during rewarming. Despite autonomic dysfunction, total peripheral resistance increased during cooling and did not normalize after rewarming. The present data show that sympathetic cardiovascular control is reduced by hypothermia and rewarming. A simultaneous systolic dysfunction is seen in rewarmed animals, caused by reduced filling of the left ventricle and impaired contractile function, in the presence of normal diastolic function. These findings show that dysfunction of the efferent sympathetic nervous system could be instrumental in development of rewarming shock. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY The present study shows impaired autonomic control of cardiovascular function after rewarming from severe hypothermia. In victims of accidental hypothermia, rewarming shock is a much feared and lethal complication. The pathophysiology causing such cardiovascular collapse appears complex. Our findings indicate that dysfunction of the autonomic nervous system is an important part of the pathophysiology. Thus the present study gives novel information, important for further development of treatment strategies in this patient group. <\/jats:p>","DOI":"10.1152\/japplphysiol.00317.2017","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T02:40:39Z","timestamp":1514169639000},"page":"850-859","source":"Crossref","is-referenced-by-count":15,"title":["Effects of hypothermia and rewarming on cardiovascular autonomic control in vivo"],"prefix":"10.1152","volume":"124","author":[{"given":"Erik Sveberg","family":"Dietrichs","sequence":"first","affiliation":[{"name":"Anesthesia and Critical Care Research Group, Department of Clinical Medicine, UiT, The Arctic University of Norway, Troms\u00f8, Norway"},{"name":"Department of Research and Education, Norwegian Air Ambulance Foundation, Dr\u00f8bak, Norway"},{"name":"Department of Clinical Pharmacology, Division of Diagnostic Services, University Hospital of North Norway, Troms\u00f8, 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