{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:04:01Z","timestamp":1792004641146,"version":"4.4.0"},"reference-count":54,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p> Previous studies have shown that subjects with sickle cell trait (SCT), \u03b1-thalassemia (\u03b1-t), and the dual hemoglobinopathy (SCT\/\u03b1-t) manifest subtle, albeit significant, differences during exercise. To better understand such differences, we assessed skeletal muscle histomorphological and energetic characteristics in 10 control HbAA subjects (C), 5 subjects with \u03b1-t (\u03b1-t), 6 SCT carriers (SCT) and 9 SCT carriers with \u03b1-t (SCT\/\u03b1-t). Subjects underwent a muscle biopsy and also performed an incremental maximal exercise and a time to exhaustion test. There were no observable differences in daily energy expenditure, maximal power output (P<jats:sub>max<\/jats:sub>), or time to exhaustion at 110% P<jats:sub>max<\/jats:sub> ( T<jats:sub>ex<\/jats:sub>) among the groups. Blood lactate concentrations measured at the end of the T<jats:sub>ex<\/jats:sub>, muscle fiber type distribution, and mean phosphofructokinase (PFK), lactate dehydrogenase (LDH), \u03b2-hydroxyacyl-CoA-dehydrogenase (HAD), and citrate synthase (CS) activities were all similar among the four groups. However, SCT was associated with a lower cytochrome- c oxidase (COx) activity in type IIa fibers ( P &lt; 0.05), and similar trends were observed in fiber types I and IIx. Trends toward lower creatine kinase (CK) activity ( P = 0.0702) and higher surface area of type IIx fibers were observed in SCT ( P = 0.0925). In summary, these findings support most of the previous observations in SCT, such as 1) similar maximal power output and associated maximal oxygen consumption (V\u0307o<jats:sub>2max<\/jats:sub>) values and 2) lower exercise performances during prolonged submaximal exercise. Furthermore, performances during short supramaximal exercise were not different in SCT. Finally, the dual hemoglobinopathy condition does not seem to affect muscle characteristics. <\/jats:p>","DOI":"10.1152\/japplphysiol.00349.2010","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T22:37:39Z","timestamp":1277419059000},"page":"728-734","source":"Crossref","is-referenced-by-count":23,"title":["Skeletal muscle structural and energetic characteristics in subjects with sickle cell trait, \u03b1-thalassemia, or dual hemoglobinopathy"],"prefix":"10.1152","volume":"109","author":[{"given":"Lucile","family":"Vincent","sequence":"first","affiliation":[{"name":"Laboratoire de Physiologie de l'Exercice EA4338, Universit\u00e9 de Savoie, Chamb\u00e9ry and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9onard","family":"F\u00e9asson","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie de l'Exercice EA4338, Universit\u00e9 Jean Monnet and"},{"name":"Unit\u00e9 de Myologie, Centre Hospitalier 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