{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:53:01Z","timestamp":1780080781339,"version":"3.54.0"},"reference-count":62,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p> To our knowledge, this study is the first to show an independent association between low resting inspiratory capacity (IC) and, severe exertional dyspnea, exercise limitation, and increased mortality risk, after accounting for the severity of airway obstruction, inspiratory muscle strength, and diffusing capacity. These results support the use of resting IC as an important independent physiological biomarker closely linked to key clinical outcomes in COPD. <\/jats:p>","DOI":"10.1152\/japplphysiol.00352.2022","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T20:13:24Z","timestamp":1660248804000},"page":"679-688","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Physiological predictors of morbidity and mortality in COPD: the relative importance of reduced inspiratory capacity and inspiratory muscle strength"],"prefix":"10.1152","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0664-5171","authenticated-orcid":false,"given":"Devin B.","family":"Phillips","sequence":"first","affiliation":[{"name":"Respiratory Investigation Unit, Department of Medicine, Queen\u2019s University and Kingston Health Sciences Centre, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"James","sequence":"additional","affiliation":[{"name":"Respiratory Investigation Unit, Department of Medicine, Queen\u2019s University and Kingston Health Sciences Centre, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor D.","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Respiratory Investigation Unit, Department of Medicine, Queen\u2019s University and Kingston Health Sciences Centre, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra G.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Respiratory Investigation Unit, Department of Medicine, Queen\u2019s University and Kingston Health Sciences Centre, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Webb","sequence":"additional","affiliation":[{"name":"Respiratory Investigation Unit, Department of Medicine, Queen\u2019s University and Kingston Health Sciences Centre, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"de-Torres","sequence":"additional","affiliation":[{"name":"Respiratory Investigation Unit, Department of Medicine, Queen\u2019s University and Kingston Health Sciences Centre, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alberto","family":"Neder","sequence":"additional","affiliation":[{"name":"Respiratory Investigation Unit, Department of Medicine, Queen\u2019s University and Kingston Health Sciences Centre, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7593-2433","authenticated-orcid":false,"given":"Denis E.","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Respiratory Investigation Unit, Department of Medicine, Queen\u2019s University and Kingston Health Sciences Centre, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200407-867OC"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.3.8630580"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0787"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-40"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2016.1158801"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2017.1281901"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021322"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.6.1952"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.13246899"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.46.5.867"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00289-2020"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2018.1398084"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(21)00502-5"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.6.2482"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.6.8520771"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0841OC"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01078.2017"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109263251304"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00120609"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201710-2140CI"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01214-2018"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035005"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034905"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00034714"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.105815"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00135514"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/resp.14045"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/956081"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00548"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00010-2017"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.06.074"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"B35","first-page":"1348","volume":"54","author":"Evans JA","year":"2009","journal-title":"Resp Care"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002741"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1113\/JP283252"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.053470"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00157711"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.052"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.11.045"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00031810"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00341.2019"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(66)90016-8"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201106-1128OC"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202109-2171OC"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.3.8630582"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00877.2018"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.4.935"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01470.2005"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01118.2020"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00116004"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00237402"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.04.033"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.041830"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1111\/resp.14170"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/resp.14187"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202108-1819PP"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.1.9608113"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2007033"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.072884"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00352.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T22:00:38Z","timestamp":1662501638000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00352.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9,1]]}},"alternative-id":["10.1152\/japplphysiol.00352.2022"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00352.2022","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,1]]},"assertion":[{"value":"2022-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}