{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:47:40Z","timestamp":1791899260509,"version":"4.3.4"},"reference-count":63,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:p>This study compared two distinct resistance exercise loading strategies (3\u20135 RM vs. 20\u201325 RM) in trained individuals, evaluating both muscular and myocellular adaptations. Our findings demonstrate that low-load resistance exercise training (LL-RET) is an effective alternative to traditional high-load strategies for increasing strength and muscle size. These results highlight that skeletal muscle growth can be achieved through various external loads, offering valuable insights for individuals seeking hypertrophy but unable to tolerate high loads.<\/jats:p>","DOI":"10.1152\/japplphysiol.00353.2025","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T11:31:34Z","timestamp":1755603094000},"page":"685-697","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Divergent strength gains but similar hypertrophy after low-load and high-load resistance exercise training in trained individuals: many roads lead to Rome"],"prefix":"10.1152","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7536-3194","authenticated-orcid":false,"given":"Kristoffer Toldnes","family":"Cumming","sequence":"first","affiliation":[{"name":"Norwegian School of Sport Sciences","place":["Norway"]},{"name":"\u00d8stfold University College","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Cecelia","family":"Elvatun","sequence":"additional","affiliation":[{"name":"Norwegian School of Sport Sciences","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kalenius","sequence":"additional","affiliation":[{"name":"The Swedish School of Sport and Health Sciences","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordan","family":"Divljak","sequence":"additional","affiliation":[{"name":"The Swedish School of Sport and Health Sciences","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-3004","authenticated-orcid":false,"given":"Truls","family":"Raastad","sequence":"additional","affiliation":[{"name":"Norwegian School of Sport Sciences","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1848-5491","authenticated-orcid":false,"given":"Niklas","family":"Psilander","sequence":"additional","affiliation":[{"name":"The Swedish School of Sport and Health Sciences","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3500-2896","authenticated-orcid":false,"given":"Oscar","family":"Horwath","sequence":"additional","affiliation":[{"name":"The Swedish School of Sport and Health Sciences","place":["Sweden"]},{"id":[{"id":"https:\/\/ror.org\/056d84691","id-type":"ROR","asserted-by":"publisher"}],"name":"Karolinska Institute","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141582"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2024.08.011"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.31.11.957"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.3.475"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50216.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4196-9"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1017\/S002966511500169X"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e318225a26f"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181915670"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00266.2024"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12493"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00402"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2010.01178.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12306"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000000958"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s40798-023-00578-4"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-002-0681-6"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90538.2008"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2018.1450898"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00154.2016"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00307.2012"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001775"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12305"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/jfmk8020051"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913935107"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.065904"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12609"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01215.2007"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00397.2018"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00464.2021"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12509"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.237008"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-013-2733-5"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2016-0645"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/s40798-023-00633-0"},{"key":"B36","volume-title":"ACSM's Guidelines for Exercise Testing and Prescription","author":"Kenney WL","year":"1995"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12808"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1113\/JP285675"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00692.2024"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00917.2018"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21369"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13034"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012033"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000002776"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00531.2006"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000177588.74448.75"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002310"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.153916"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00297"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00704.2022"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00053.2021"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2019-0263"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00394.2024"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-015-3243-4"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202202065RR"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101096R"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002088"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102372"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00200.2022"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00424.2021"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00635"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12961"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-001-0533-9"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00353.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T15:51:11Z","timestamp":1758642671000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00353.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9,1]]}},"alternative-id":["10.1152\/japplphysiol.00353.2025"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00353.2025","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,1]]},"assertion":[{"value":"2025-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}