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Using functional magnetic resonance imaging techniques, we examined responses over the brain to voluntary forced expiratory loading, a task that CCHS patients can perform but that results in impaired rapid heart rate variation patterns normally associated with the loading challenge. Increased signals emerged in control ( n = 14) over CCHS ( n = 13; ventilator dependent during sleep but not waking) subjects in the cingulate and right parietal cortex, cerebellar cortex and fastigial nucleus, and basal ganglia, whereas anterior cerebellar cortical sites and deep nuclei, dorsal midbrain, and dorsal pons showed increased signals in the patient group. The dorsal and ventral medulla showed delayed responses in CCHS patients. Primary motor and sensory areas bordering the central sulcus showed comparable responses in both groups. The delayed responses in medullary sensory and output regions and the aberrant reactions in cerebellar and pontine sensorimotor coordination areas suggest that rapid cardiorespiratory integration deficits in CCHS may stem from defects in these sites. Additional autonomic and perceptual motor deficits may derive from cingulate and parietal cortex aberrations.<\/jats:p>","DOI":"10.1152\/japplphysiol.00359.2004","type":"journal-article","created":{"date-parts":[[2004,7,17]],"date-time":"2004-07-17T00:56:21Z","timestamp":1090025781000},"page":"1897-1907","source":"Crossref","is-referenced-by-count":52,"title":["fMRI signal changes in response to forced expiratory loading in congenital central hypoventilation syndrome"],"prefix":"10.1152","volume":"97","author":[{"given":"K. E.","family":"Macey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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