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Nitric oxide (NO) and hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) are two gaseous cellular signaling molecules that play key roles in several physiological functions involved in maintaining vascular homeostasis including vasodilation, anti-inflammation, and vascular growth. Apart from the aforementioned functions, NO and H<jats:sub>2<\/jats:sub>S are believed to mediate hypoxic responses and serve as O<jats:sub>2<\/jats:sub>chemosensors in biological systems. 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