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Rectus muscle serial sections were examined for coexpression of eight MyHC isoforms. A continuum was seen in single myofiber shortening velocities as well as force generation, both in absolute force (g) and specific tension (kN\/m<jats:sup>2<\/jats:sup>). Shortening velocity correlated with MyHCIIB, IIA, and I content, the more abundant MyHC isoforms expressed within individual myofibers. Importantly, single fibers with similar or identical shortening velocities expressed significantly different ratios of MyHC isoforms. The vast majority of myofibers in both the orbital and global layers expressed more than one MyHC isoform, with up to six isoforms in single fiber segments. MyHC expression varied significantly and unpredictably along the length of single myofibers. Thus EOM myofibers represent a continuum in their histological and physiological characteristics. This continuum would facilitate fine motor control of eye position, speed, and direction of movement in all positions of gaze and with all types of eye movements\u2014from slow vergence movements to fast saccades. To fully understand how the brain controls eye position and movements, it is critical that this significant EOM myofiber heterogeneity be integrated into hypotheses of oculomotor control.<\/jats:p>","DOI":"10.1152\/japplphysiol.00368.2011","type":"journal-article","created":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T03:02:35Z","timestamp":1311303755000},"page":"1178-1189","source":"Crossref","is-referenced-by-count":34,"title":["A continuum of myofibers in adult rabbit extraocular muscle: force, shortening velocity, and patterns of myosin heavy chain colocalization"],"prefix":"10.1152","volume":"111","author":[{"given":"Linda K.","family":"McLoon","sequence":"first","affiliation":[{"name":"Departments of 1Ophthalmology and"},{"name":"Neuroscience and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han na","family":"Park","sequence":"additional","affiliation":[{"name":"Departments of 1Ophthalmology 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