{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:25:43Z","timestamp":1781659543543,"version":"3.54.5"},"reference-count":50,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2002,2,1]]},"abstract":"<jats:p> We aimed to assess the influence of lateral decubitus postures and positive end-expiratory pressure (PEEP) on the regional distribution of ventilation and perfusion. We measured regional ventilation (V\u02d9a) and regional blood flow (Q\u02d9) in six anesthetized, mechanically ventilated dogs in the left (LLD) and right lateral decubitus (RLD) postures with and without 10 cmH<jats:sub>2<\/jats:sub>O PEEP. Q\u02d9 was measured by use of intravenously injected 15-\u03bcm fluorescent microspheres, and V\u02d9a was measured by aerosolized 1-\u03bcm fluorescent microspheres. Fluorescence was analyzed in lung pieces \u223c1.7 cm<jats:sup>3<\/jats:sup> in volume. Multiple linear regression analysis was used to evaluate three-dimensional spatial gradients ofQ\u02d9, V\u02d9a, the ratio V\u02d9a\/Q\u02d9, and regional Po <jats:sub>2<\/jats:sub> (Pr<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub>) in both lungs. In the LLD posture, a gravity-dependent vertical gradient in Q\u02d9 was observed in both lungs in conjunction with a reduced blood flow and Pr<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub> to the dependent left lung. Change from the LLD to the RLD or 10 cmH<jats:sub>2<\/jats:sub>O PEEP increased localV\u02d9a\/Q\u02d9 and Pr<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub> in the left lung and minimized any role of hypoxia. The greatest reduction in individual lung volume occurred to the left lung in the LLD posture. We conclude that lung distortion caused by the weight of the heart and abdomen is greater in the LLD posture and influences both Q\u02d9 andV\u02d9a, and ultimately gas exchange. In this respect, the smaller left lung was the most susceptible to impaired gas exchange in the LLD posture. <\/jats:p>","DOI":"10.1152\/japplphysiol.00377.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:39:58Z","timestamp":1425415198000},"page":"745-762","source":"Crossref","is-referenced-by-count":41,"title":["Spatial distribution of ventilation and perfusion  in anesthetized dogs in lateral postures"],"prefix":"10.1152","volume":"92","author":[{"given":"Hung","family":"Chang","sequence":"first","affiliation":[{"name":"Departments of Physiology and Biophysics,"},{"name":"Division of Chest Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical School, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Lai-Fook","sequence":"additional","affiliation":[{"name":"Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen B.","family":"Domino","sequence":"additional","affiliation":[{"name":"Anesthesiology, University of Washington, Seattle, Washington 98195;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel","family":"Schimmel","sequence":"additional","affiliation":[{"name":"Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics,"},{"name":"Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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