{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:34:39Z","timestamp":1790289279865,"version":"4.1.0"},"reference-count":58,"publisher":"American Physiological Society","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306956\/2021-7"],"award-info":[{"award-number":["306956\/2021-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01485-22"],"award-info":[{"award-number":["APQ-01485-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior - Brasil","doi-asserted-by":"crossref","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:p> This study reveals that combined exercise improves tolerance to physical effort, prevents increases in pulmonary artery resistance, and conserves the right heart function during the progression of pulmonary arterial hypertension. Our analyses show that combined exercise hinders harmful right ventricular and lung structural remodeling and oxidative stress, which reflects in the maintenance of right ventricular myocytes\u2019 contractile function by preserving the intracellular calcium cycling. An attenuated progression of the disease impacts positively on its prognosis. <\/jats:p>","DOI":"10.1152\/japplphysiol.00379.2024","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T15:50:16Z","timestamp":1732895416000},"page":"182-194","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Combined exercise hinders the progression of pulmonary and right heart harmful remodeling in monocrotaline-induced pulmonary arterial hypertension"],"prefix":"10.1152","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3012-1327","authenticated-orcid":false,"given":"Luciano Bernardes","family":"Leite","sequence":"first","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u00f4ncio Lopes","family":"Soares","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Martins Oliveira","family":"Portes","sequence":"additional","affiliation":[{"name":"Federal University of Ouro Preto","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Aparecida Fonseca","family":"da Silva","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u00eds Rodrigues","family":"Dias","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thayana In\u00e1cia","family":"Soares","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian Quint\u00e3o","family":"Assis","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Ot\u00e1vio","family":"Guimar\u00e3es-Ervilha","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Ara\u00fajo","family":"Carneiro-J\u00fanior","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Forte","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Bragan\u00e7a","place":["Portugal"]},{"name":"Higher Instituto of Educational Sciences of the Douro","place":["Portugal"]},{"name":"Higher Institute of Educational Sciences of the Douro","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Machado-Neves","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Correna Carlo","family":"Reis","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-4024","authenticated-orcid":false,"given":"Ant\u00f4nio Jos\u00e9","family":"Natali","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199707000-00018"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1980.239.5.H692"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00076-5"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02531-1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120024"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v2.i10.316"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2019.110579"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117848"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.05.012"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1023\/b.0000026047.48534.50"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2008.04936.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-021-02642-9"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2016.06.006"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.05.050"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.11.066"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2020.01.009"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122128"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-021-00660-y"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01233"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-017-2995-z"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000254415.31362.a7"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24408"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.02.019"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000065"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15026"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.12.026"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-013-9542-9"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.117168"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000928"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116974"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00262.2015"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-016-2937-1"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1139\/h04-002"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1351254"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.6.1072"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-024-00270-z"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.01.013"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.101428"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00725.2017"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2015.12.012"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.1.33"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42083-8"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.07.054"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(94)33040-9"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.36660\/abc.20210681"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0272-9"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2012-0261"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.03.044"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.11.6.7946395"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajme.2017.09.001"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/457848"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2326-1"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181b2e899"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/415198a"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-015-0514-5"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12166"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00379.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T19:13:25Z","timestamp":1744312405000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00379.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,1]]}},"alternative-id":["10.1152\/japplphysiol.00379.2024"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00379.2024","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]},"assertion":[{"value":"2024-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}