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To better resolve the role of D<jats:sub>2<\/jats:sub> receptors, we examined afferent nerve activity, catecholamine content and release, and ventilation of genetically engineered mice lacking D<jats:sub>2<\/jats:sub> receptors (D<jats:sub>2<\/jats:sub><jats:sup>\u2212\/\u2212<\/jats:sup> mice). Single-unit afferent nerve activities of D<jats:sub>2<\/jats:sub><jats:sup>\u2212\/\u2212<\/jats:sup> mice in vitro were significantly reduced by 45% and 25% compared with wild-type (WT) mice during superfusion with saline equilibrated with mild hypoxia (Po<jats:sub>2<\/jats:sub> \u223c50 Torr) or severe hypoxia (Po<jats:sub>2<\/jats:sub> \u223c20 Torr), respectively. Catecholamine release in D<jats:sub>2<\/jats:sub><jats:sup>\u2212\/\u2212<\/jats:sup> mice was enhanced by 125% in mild hypoxia and 75% in severe hypoxia compared with WT mice, and the rate of rise was increased in D<jats:sub>2<\/jats:sub><jats:sup>\u2212\/\u2212<\/jats:sup> mice. We conclude that CB transduction of hypoxia is still present in D<jats:sub>2<\/jats:sub><jats:sup>\u2212\/\u2212<\/jats:sup> mice, but the response magnitude is reduced. However, the ventilatory response to acute hypoxia is maintained, perhaps because of an enhanced processing of chemoreceptor input by brain stem respiratory nuclei. <\/jats:p>","DOI":"10.1152\/japplphysiol.00391.2007","type":"journal-article","created":{"date-parts":[[2007,8,2]],"date-time":"2007-08-02T20:59:25Z","timestamp":1186088365000},"page":"1269-1275","source":"Crossref","is-referenced-by-count":23,"title":["Hypoxia transduction by carotid body chemoreceptors in mice lacking dopamine D<sub>2<\/sub> receptors"],"prefix":"10.1152","volume":"103","author":[{"given":"J.","family":"Prieto-Lloret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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