{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:18:10Z","timestamp":1792876690103,"version":"4.5.0"},"reference-count":25,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p> Sustained hypoxia (SH) has been shown to cause profound morphological and cellular changes in carotid body (CB). However, results regarding whether SH causes CB type I cell proliferation are conflicting. By using bromodeoxyuridine, a uridine analog that is stably incorporated into cells undergoing DNA synthesis, we have found that SH causes the type I cell proliferation in the CB; the proliferation occurs mainly during the first 1\u20133 days of hypoxic exposure. Moreover, the new cells survive for at least 1 mo after the return to normoxia. Also, SH does not cause any cell death in CB as examined by the terminal deoxynucleotidyl transferase-mediated dUTP-X nick-end labeling assay. Taken together, our results suggest that SH stimulates CB type I cell proliferation, which may produce long-lasting changes in CB morphology and function. <\/jats:p>","DOI":"10.1152\/japplphysiol.00393.2007","type":"journal-article","created":{"date-parts":[[2007,12,20]],"date-time":"2007-12-20T21:00:16Z","timestamp":1198184416000},"page":"803-808","source":"Crossref","is-referenced-by-count":53,"title":["Sustained hypoxia-induced proliferation of carotid body type I cells in rats"],"prefix":"10.1152","volume":"104","author":[{"given":"Z.-Y.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"E. B.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. E.","family":"Bjorling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. S.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. E.","family":"Bisgard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00011-3"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1159\/000146222"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.5.1504"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2572-1_10"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-06-02131.1999"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00454.2001"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2000000300012"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1984.sp002807"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.26.14686"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90458-L"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.4.829"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2966-8_5"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(01)00042-5"},{"key":"R14","unstructured":"Le Douarin N. The Neural Crest. London: Cambridge University Press, 1982."},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.5.1430"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0530113100"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8539"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10199"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199912160-00003"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200110290-00028"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1007\/BF01148336"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.6.2287"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.10.5565"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10191"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-028608-9.50006-5"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00393.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:13:17Z","timestamp":1567966397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00393.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1152\/japplphysiol.00393.2007"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00393.2007","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}