{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:54:23Z","timestamp":1785405263140,"version":"3.56.0"},"reference-count":72,"publisher":"American Physiological Society","issue":"3","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.49"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG072973"],"award-info":[{"award-number":["P30 AG072973"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG081304"],"award-info":[{"award-number":["R01 AG081304"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:p>Our pilot study demonstrated promising results for heat therapy (HT) via hot water immersion in older adults at risk for Alzheimer\u2019s disease due to metabolic factors. Despite a relatively short intervention, significant improvements in mean arterial pressure, diastolic blood pressure, and cerebral blood flow postintervention were observed. High participant adherence, overall satisfaction, and minimal adverse events suggest HT\u2019s feasibility. These findings highlight HT\u2019s potential as an effective alternative intervention for cardiometabolic dysfunction in at-risk populations.<\/jats:p>","DOI":"10.1152\/japplphysiol.00396.2024","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T02:01:29Z","timestamp":1737338489000},"page":"720-730","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Improving glycemic control via heat therapy in older adults at risk for Alzheimer\u2019s disease (FIGHT-AD): a pilot study"],"prefix":"10.1152","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6181-8035","authenticated-orcid":false,"given":"Anneka E.","family":"Blankenship","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036c9yv20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Kansas Medical Center","place":["United States"]},{"name":"University of Kansas Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riley","family":"Kemna","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036c9yv20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Kansas Medical Center","place":["United States"]},{"name":"University of Kansas Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Kueck","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036c9yv20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Kansas Medical Center","place":["United States"]},{"name":"University of Kansas Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"John","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036c9yv20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Kansas Medical Center","place":["United States"]},{"name":"University of Kansas Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Vitztum","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Yoksh","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Mahnken","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036c9yv20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Kansas Medical Center","place":["United States"]},{"name":"University of Kansas Medical Center","place":["United States"]},{"name":"University of Kansas Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5181-7131","authenticated-orcid":false,"given":"Eric D.","family":"Vidoni","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036c9yv20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Kansas Medical Center","place":["United States"]},{"name":"University of Kansas Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill K.","family":"Morris","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036c9yv20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Kansas Medical Center","place":["United States"]},{"name":"University of Kansas Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3990-7246","authenticated-orcid":false,"given":"Paige C.","family":"Geiger","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036c9yv20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Kansas Medical Center","place":["United States"]},{"name":"University of Kansas Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.5.661"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.2.474"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009106"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.53.9.1937"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.02.013"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.04.012"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2337\/diab.23.8.713"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10242"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12239"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79742"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.04.017"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.162263"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170547"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2016.09.009"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2023.1109-1"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161163"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1361772"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611721104"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00926.2020"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16676826"},{"key":"B22","volume-title":"Older Americans 2020: Key Indicators of Well-Being","author":"Federal Interagency Forum on Aging-Related Statistics (Forum)","year":"2020"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909163411216"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00549.2018"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-020-01924-x"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00078.2019"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00222.2023"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00151.2019"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00645.2021"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00141.2020"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00291.2020"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00019.2020"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00407.2018"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1177\/2047487318805158"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.03.003"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0265860"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.2174\/0115672050271523231111192725"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-019-00164-5"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.03.009"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0755-1"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02195-x"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.013"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.6117"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab223"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-023-01314-1"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00404.2016"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-017-0008-z"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00147.2016"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.91.10.2582"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000178"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.652859"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00336.2021"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(01)01824-1"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2023.104536"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1113\/JP272453"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1113\/JP276559"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01098.2018"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00383.2018"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00519.2016"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00148.2008"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1070"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00849.2010"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.01.049"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00286.2014"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqab001"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00168.2020"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac418"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00353.2015"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140066"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00780.2021"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2014.05.003"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2011.06.003"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00396.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T15:13:25Z","timestamp":1744298005000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00396.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,1]]}},"alternative-id":["10.1152\/japplphysiol.00396.2024"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00396.2024","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,1]]},"assertion":[{"value":"2024-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}