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Moreover, synchrony of daily molecular and physiological rhythms is integral to healthy organ growth and renewal. Disruption of these rhythms adversely affects normal growth, also the remodeling mechanisms in disease, leading to gross abnormalities in heart and vessels. These observations provide new insights into the pathogenesis, diagnosis, treatment, and prevention of heart disease. In this review, we focus on the recent advances in circadian biology and cardiovascular function, with particular emphasis on how this applies to human myocardial hypertrophy and heart failure, and the implications and importance for translational medicine.<\/jats:p>","DOI":"10.1152\/japplphysiol.00426.2009","type":"journal-article","created":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T01:53:48Z","timestamp":1245981228000},"page":"1318-1327","source":"Crossref","is-referenced-by-count":52,"title":["Diurnal physiology: core principles with application to the pathogenesis, diagnosis, prevention, and treatment of myocardial hypertrophy and failure"],"prefix":"10.1152","volume":"107","author":[{"given":"Michael J.","family":"Sole","sequence":"first","affiliation":[{"name":"Toronto General Hospital Research Institute, University Health Network, Heart and Stroke, Richard Lewar Centre of Excellence, University of Toronto, Toronto; 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