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The hypotheses of this study were that glutamine administration to SCI rats would lead to improved functional recovery and more preserved MHC phenotypes in representative locomotor muscles. Male Wistar rats were divided into four groups: healthy, sham with laminectomy, laminectomized SCI untreated, and laminectomized SCI treated with glutamine. Functional performance was measured weekly for 6 wk using Basso-Beattie-Bresnahan scale and angle board methods. MHC composition of rat soleus and extensor digitorum longus muscles was determined using SDS-PAGE. Glutamine-treated rats had significantly higher angle board scores ( P &lt; 0.001) and Basso-Beattie-Bresnahan scores ( P &lt; 0.01) than untreated SCI rats. Soleus of healthy rats contained 94% type 1 myosin isoform. Treated rats maintained 68%, which was significantly ( P &lt; 0.001) greater than 28% in untreated rats. The extensor digitorum longus of healthy rats contained 55% type 2b myosin. There was a significant ( P &lt; 0.001) decrease in this isoform following SCI, but no significant difference between treated and untreated groups. There were strong correlations between higher functional scores and more preserved MHC phenotypes. Our findings suggest glutamine improves functional recovery and helps preserve myosin profile by reducing secondary SCI, thereby maintaining more nerves.<\/jats:p>","DOI":"10.1152\/japplphysiol.00428.2006","type":"journal-article","created":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T01:05:42Z","timestamp":1150419942000},"page":"1045-1052","source":"Crossref","is-referenced-by-count":11,"title":["The effect of glutamine on locomotor performance and skeletal muscle myosins following spinal cord injury in rats"],"prefix":"10.1152","volume":"101","author":[{"given":"Jamie D.","family":"Golding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah T. 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