{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:35:15Z","timestamp":1783478115531,"version":"3.55.0"},"reference-count":131,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG059715-01"],"award-info":[{"award-number":["R01 AG059715-01"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of California Center for Research and Education"}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:p> To our knowledge, our investigation is the first to demonstrate changes in lipolysis during an oral glucose tolerance test (OGTT) in healthy young and older individuals. Plasma glycerol and free fatty acid concentrations changed after glycerol rate of appearance (Ra), indicating that plasma concentrations are incomplete surrogates of the lipolytic rate. Moreover, simultaneous determinations of substrate oxidation rates are interpreted to indicate that metabolic inflexibility in aging is characterized by delayed changes in postprandial substrate utilization related to the lipolytic rate. <\/jats:p>","DOI":"10.1152\/japplphysiol.00437.2024","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T18:01:25Z","timestamp":1725559285000},"page":"1200-1219","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Aging delays the suppression of lipolysis and fatty acid oxidation in the postprandial period"],"prefix":"10.1152","volume":"137","author":[{"given":"Adam D.","family":"Osmond","sequence":"first","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7862-293X","authenticated-orcid":false,"given":"Robert G.","family":"Leija","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-4960","authenticated-orcid":false,"given":"Jose A.","family":"Arevalo","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey C.","family":"Curl","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin J.","family":"Duong","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin J.","family":"Huie","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh","family":"Masharani","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, University of California, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-1629","authenticated-orcid":false,"given":"George A.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.6.2253"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1692"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.258.6.E923"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.6.E1130"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113489"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-022-02986-w"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000927"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00981.2004"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(93)90088-6"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(72)90051-0"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2337\/diab.26.7.693"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.46.10.1586"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108486"},{"key":"B14","first-page":"167","volume":"138","author":"Tancredi RG","year":"1976","journal-title":"Johns Hopkins Med J"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00116.2010"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0349"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00474.2005"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(63)91500-9"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116603"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2337\/diab.36.11.1341"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(82)90163-9"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1042\/cs0790167"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1991.261.3.E304"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1042\/cs0820219"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.10.6898"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1994.266.3.E501"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.5.8495"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb02443.x"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.10.2528"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.137331"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2019-001109"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.01.008"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00142.2017"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.7.1612"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117252"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/102054"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/BF00284457"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/BF02624820"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00497.2022"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.10.088"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806409200"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.02.012"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(74)90081-x"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1964.207.6.1226"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1963.205.5.902"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.258.5.E888"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00104.2006"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00091.2024"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00183.2024"},{"key":"B50","unstructured":"Liguori G; American College of Sports Medicine. ACSM's Guidelines for Exercise Testing and Prescription. Philadelphia: Wolters Kluwer, 2022, p. xxxiv, 513."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00393.2024"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-00993-1"},{"key":"B53","first-page":"211","volume-title":"Methods of Enzymatic Analysis","author":"Weiland O","year":"1971"},{"key":"B54","first-page":"266","volume-title":"Methods of Enzymatic Analysis","author":"Hohorst H-J","year":"1971"},{"key":"B55","unstructured":"Wolfe RR. Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. New York, NY: Wiley-Liss, 1992, p. vii, 471 p."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00685.2004"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.3.1175"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2006.263.6.E1063"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1487"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-13-47"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1177\/1932296818805074"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000071108.00234.0E"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1515"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00260"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031314"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00366.2002"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.97"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.12997\/jla.2020.9.1.110"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.2337\/diab.35.12.1326"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.1.57"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.8.2426"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.362"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25151"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/BF03340110"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.1.119"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.3.7330"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.5.7460"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39100-8"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1172\/jci110211"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.278.4.E669"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112682"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.271.6.E983"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.274.5.E785"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.259.5.E736"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.175629"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.276.2.E233"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.265.3.E504"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.259.4.E542"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.265.6.E821"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.270.4.E733"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.31.11.957"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1987.253.4.E376"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25758"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24332"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.2337\/diab.28.12.1095"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.suppl_2.465"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.7.1738"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1172\/jci110914"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.4.12.370"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/54.6.963"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.258.2.E382"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.11.1588"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080018"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082889"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501559102"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-6-1268"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1989.257.1.E49"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.275.5.E853"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.6.2097"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.6.1270"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200958200"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.7.5.465"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/37.6.941"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1007\/BF00252263"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00365.2002"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1042\/cs0670213"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1053\/bega.2001.0262"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.04.004"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.01.004"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.265.3.E380"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1101\/gad.209296.112"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(91)90035-u"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1042\/cs0840099"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(80)90078-5"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(81)90092-5"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1172\/jci110966"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(80)90090-6"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1172\/jci110794"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00437.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T17:43:00Z","timestamp":1732210980000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00437.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,1]]},"references-count":131,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11,1]]}},"alternative-id":["10.1152\/japplphysiol.00437.2024"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00437.2024","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,1]]},"assertion":[{"value":"2024-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}