{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:55:22Z","timestamp":1787507722548,"version":"build-2736575974"},"reference-count":36,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100000925","name":"Department of Health, Australian Government | National Health and Medical Research Council (NHMRC)","doi-asserted-by":"publisher","award":["APP113902"],"award-info":[{"award-number":["APP113902"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health, Australian Government | National Health and Medical Research Council (NHMRC)","doi-asserted-by":"publisher","award":["APP1058537"],"award-info":[{"award-number":["APP1058537"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Synchrotron Access Program","award":["ISAP11508"],"award-info":[{"award-number":["ISAP11508"]}]},{"name":"Vidi Grant, The Netherlands Organisation for Health Research and Development","award":["NWO-Vidi 2015\/\/2016"],"award-info":[{"award-number":["NWO-Vidi 2015\/\/2016"]}]},{"name":"ARC Australian Research Fellowship","award":["FT160100454"],"award-info":[{"award-number":["FT160100454"]}]},{"name":"Monash University Bridging Postdoctoral Fellowship","award":["BPF17-0066"],"award-info":[{"award-number":["BPF17-0066"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:p>\n                    Excessive liquid in airways and\/or distal lung tissue may underpin the respiratory morbidity associated with transient tachypnea of the newborn (TTN). However, its effects on lung aeration and respiratory function following birth are unknown. We investigated the effect of elevated airway liquid volumes on newborn respiratory function. Near-term rabbit kittens (30 days gestation; term ~32 days) were delivered, had their lung liquid-drained, and either had no liquid replaced (control; n = 7) or 30 ml\/kg of liquid re-added to the airways [liquid added (LA); n = 7]. Kittens were mechanically ventilated in a plethysmograph. Measures of chest and lung parameters, uniformity of lung aeration, and airway size were analyzed using phase contrast X-ray imaging. The maximum peak inflation pressure required to recruit a tidal volume of 8 ml\/kg was significantly greater in LA compared with control kittens (35.0\u2009\u00b1\u20090.7 vs. 26.8\u2009\u00b1\u20090.4 cmH\n                    <jats:sub>2<\/jats:sub>\n                    O, P &lt; 0.001). LA kittens required greater time to achieve lung aeration (106\u2009\u00b1\u200914 vs. 60\u2009\u00b1\u20096 inflations, P = 0.03) and had expanded chest walls, as evidenced by an increased total chest area (32\u2009\u00b1\u20099%, P &lt; 0.0001), lung height (17\u2009\u00b1\u20096%, P = 0.02), and curvature of the diaphragm (19\u2009\u00b1\u20098%, P = 0.04). LA kittens had lower functional residual capacity during stepwise changes in positive end-expiratory pressures (5, 3, 0, and 5 cmH\n                    <jats:sub>2<\/jats:sub>\n                    0). Elevated lung liquid volumes had marked adverse effects on lung structure and function in the immediate neonatal period and reduced the ability of the lung to aerate efficiently. We speculate that elevated airway liquid volumes may underlie the initial morbidity in near-term babies with TTN after birth.\n                  <\/jats:p>\n                  <jats:p>NEW &amp; NOTEWORTHY Transient tachypnea of the newborn reduces respiratory function in newborns and is thought to result due to elevated airway liquid volumes following birth. However, the effect of elevated airway liquid volumes on neonatal respiratory function is unknown. Using phase contrast X-ray imaging, we show that elevated airway liquid volumes have adverse effects on lung structure and function in the immediate newborn period, which may underlie the pathology of TTN in near-term babies after birth.<\/jats:p>","DOI":"10.1152\/japplphysiol.00464.2017","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T20:10:22Z","timestamp":1501791022000},"page":"1204-1213","source":"Crossref","is-referenced-by-count":34,"title":["Elevated airway liquid volumes at birth: a potential cause of transient tachypnea of the newborn"],"prefix":"10.1152","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9849-5958","authenticated-orcid":false,"given":"Erin V.","family":"McGillick","sequence":"first","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia;"},{"name":"Department of Obstetrics and Gynaecology Monash University, Melbourne, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Physics and Astronomy, Monash University, Melbourne, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia;"},{"name":"Department of Obstetrics and Gynaecology Monash University, Melbourne, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan B.","family":"te Pas","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly J.","family":"Crossley","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia;"},{"name":"Department of Obstetrics and Gynaecology Monash University, Melbourne, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan J.","family":"Wallace","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia;"},{"name":"Department of Obstetrics and Gynaecology Monash University, Melbourne, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus J.","family":"Kitchen","sequence":"additional","affiliation":[{"name":"School of Physics and Astronomy, Monash University, Melbourne, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Radiation Sciences, Monash University, Melbourne, Victoria, Australia;"},{"name":"Department of Medical Imaging, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren T.","family":"Kerr","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia;"},{"name":"Department of Obstetrics and Gynaecology Monash University, Melbourne, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"DeKoninck","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia;"},{"name":"Department of Obstetrics and Gynaecology Monash University, Melbourne, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"Dekker","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Thio","sequence":"additional","affiliation":[{"name":"Women\u2019s Newborn Research Centre, The Royal Women\u2019s Hospital, Melbourne, Victoria, Australia;"},{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Australia; 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