{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:33:42Z","timestamp":1779082422763,"version":"3.51.4"},"reference-count":34,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p> Pulmonary hypertension on heart failure (HF) limits exercise capacity and survival probably because of associated right ventricular (RV) failure. This study investigated the mechanisms of RV function adaptation to early pulmonary hypertension in experimental HF. Seven weeks of rapid ventricular pacing in six dogs induced a HF characterized by cardiomegaly and decreased left ventricular ejection fraction. Compared with eight control dogs, pulmonary hypertension was borderline, with a mean pulmonary artery pressure increased to only 23 \u00b1 2 (means \u00b1 SE) mmHg. However, the pulmonary vascular impedance spectrum was globally shifted to higher pressures, with an increase in 0 Hz impedance (resistance) to 662 \u00b1 69 vs. 455 \u00b1 41 dynes\u00b7cm<jats:sup>\u22125<\/jats:sup>\u00b7m<jats:sup>2<\/jats:sup> in controls ( P &lt; 0.01) and in characteristic impedance to 183 \u00b1 20 vs. 104 \u00b1 7 dynes\u00b7cm<jats:sup>\u22125<\/jats:sup>\u00b7m<jats:sup>2<\/jats:sup> in controls ( P &lt; 0.01). There was no change in RV end-systolic elastance (Ees), but arterial elastance (Ea) was increased to 1.8 \u00b1 0.3 vs. 0.9 \u00b1 0.1 mmHg\/ml in controls so that RV-arterial coupling defined by the Ees-to-Ea ratio (Ees\/Ea) was decreased to 0.8 \u00b1 0.1 vs. 1.5 \u00b1 0.1 in controls ( P &lt; 0.01). Inhaled nitric oxide, 40 ppm or 5 \u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> nitroprusside iv, did not affect Ees\/Ea. Fifty milligrams (iv) of milrinone increased Ees\/Ea to 1.6 \u00b1 0.2 by an isolated increase in Ees. We conclude that overpacing-induced HF is accompanied by a borderline pulmonary hypertension but profound RV-arterial uncoupling explained by the failure of RV systolic function to adapt combined effects of increased pulmonary arterial resistance and elastance. <\/jats:p>","DOI":"10.1152\/japplphysiol.00467.2010","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T03:45:31Z","timestamp":1281066331000},"page":"1080-1085","source":"Crossref","is-referenced-by-count":55,"title":["Early right ventriculo-arterial uncoupling in borderline pulmonary hypertension on experimental heart failure"],"prefix":"10.1152","volume":"109","author":[{"given":"Alberto","family":"Pagnamenta","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Dewachter","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"McEntee","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Fesler","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Brimioulle","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Erasme Academic Hospital, Free University of Brussels, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Naeije","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00048-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(98)70336-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90496-0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01023.2002"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.674028"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000013771.30198.82"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90050-W"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200003000-00031"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.23.2764"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00332.2006"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01102-5"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00399-3"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.653576"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.9.2250"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.008"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022021"},{"key":"B17","first-page":"331","volume":"7","author":"Kirklin JK","year":"1988","journal-title":"J Heart Transplant"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143138.02493.DD"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.6.1770"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.3.1010"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.6.2780"},{"key":"B22","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1161\/CIRCULATIONAHA.109.192230","volume":"119","author":"McLaughlin VV","year":"2009","journal-title":"Circulation"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.14.1718"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00419.2003"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(91)90580-B"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.4.8143050"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(98)00070-9"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00615.2004"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.040469"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000053443.27512.33"},{"key":"B31","volume-title":"Cardiac Contraction and the Pressure-Volume Relationship","author":"Sagawa K","year":"1988"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00592-X"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl404"},{"key":"B34","unstructured":"Winer BJ. 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