{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:12:58Z","timestamp":1768461178625,"version":"3.49.0"},"reference-count":36,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:p> The present study tests a hypothesis that cardioprotective effects mediated by autologous adipose-derived stem cells (ADSC) in rats afflicted with insulin-dependent diabetes mellitus (IDDM) may be synergistically enhanced by oral treatment with green tea epigallocatechin gallate (EGCG). Wistar rats were divided into sham, DM, DM+ADSC (autologous transplanted 1 \u00d7 10<jats:sup>6<\/jats:sup> cells per rat), and DM+ADSC+E (E, green tea oral administration EGCG). Heart tissues were isolated from all rats, and investigations were performed after 2-mo treatment. In the sham, DM, and DM+ADSC groups, we found that DM induced cardiac dysfunction (sham and DM) and autologous ADSC transplantation could partially recover cardiac functions (DM and DM+ADSC) in DM rats. Compared with DM+ADSC, significant improvement in cardiac functions can be observed in DM+ADSC+E in echocardiographic data, histological observations, and even cellular protein expression. Oral green tea EGCG administration and autologous ADSC transplantation show synergistically beneficial effects on diabetic cardiac myopathy in DM rats. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY Cardiomyopathy can be induced in rats with diabetes mellitus (DM). Heart function can be restored in DM rats with adipose-derived stem cell treatment. Oral epigallocatechin gallate (EGCG) administration synergistically enhances cardiac function in DM rats with stem cell treatment. The EGCG and stem cell treatment cross-effect occurs via survival protein expression. <\/jats:p>","DOI":"10.1152\/japplphysiol.00471.2016","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T00:55:22Z","timestamp":1495760122000},"page":"1081-1091","source":"Crossref","is-referenced-by-count":18,"title":["Green tea epigallocatechin gallate enhances cardiac function restoration through survival signaling expression in diabetes mellitus rats with autologous adipose tissue-derived stem cells"],"prefix":"10.1152","volume":"123","author":[{"given":"Tung-Sheng","family":"Chen","sequence":"first","affiliation":[{"name":"Biomaterials Translational Research Center, China Medical University Hospital, Taichung, Taiwan;"},{"name":"Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Show-Yih","family":"Liou","sequence":"additional","affiliation":[{"name":"Formosan Blood Purification Foundation, Taipei, Taiwan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hua","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Sports Sciences, University of Taipei, Taipei, Taiwan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lung-Fa","family":"Pan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Armed Force Taichung General Hospital, Taichung, Taiwan;"},{"name":"Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Lan","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan;"},{"name":"Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery","family":"Liou","sequence":"additional","affiliation":[{"name":"Comprehensive Weight Management Center, Taipei Medical University Hospital, Taipei, Taiwan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. Vijaya","family":"Padma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Bharathiar University, Coimbatore, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Hsu","family":"Yao","sequence":"additional","affiliation":[{"name":"Biomaterials Translational Research Center, China Medical University Hospital, Taichung, Taiwan;"},{"name":"Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan;"},{"name":"School of Chinese Medicine, China Medical University, Taichung, Taiwan;"},{"name":"Department of Biomedical Informatics, Asia University, Taichung, Taiwan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Wen","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, China Medical University, Taichung, Taiwan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan;"},{"name":"Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan;"},{"name":"Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan; and"},{"name":"Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2014.11.008"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/872504"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0275"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/neq075"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126537"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-21-56"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.01.031"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1083"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2010.0009"},{"key":"B10","first-page":"3714","volume":"7","author":"Dong X","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2014"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61402-1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0574"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.09.009"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomed.2011.12.004"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00672.2012"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.05.145"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2015.07.024"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/scrt207"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.29"},{"key":"B21","first-page":"1345","volume":"9","author":"Lasaite L","year":"2014","journal-title":"Nat Prod Commun"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.08.161"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22086"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091163"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.05.012"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1021\/jf101606s"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3945\/an.114.007690"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2014.3265"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.11.013"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2174\/138161211797904163"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/stem.556"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1159\/000374021"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-014-8422-2"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24459"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1021\/mp400258d"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-006-0308-z"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00471.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T01:29:59Z","timestamp":1567992599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00471.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,1]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11,1]]}},"alternative-id":["10.1152\/japplphysiol.00471.2016"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00471.2016","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,1]]}}}