{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:58:35Z","timestamp":1781045915257,"version":"3.54.1"},"reference-count":20,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL140231"],"award-info":[{"award-number":["R01 HL140231"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013017","name":"Vanderbilt University Medical Center","doi-asserted-by":"publisher","award":["H. William Scott, Jr. Chair in Surgery"],"award-info":[{"award-number":["H. William Scott, Jr. Chair in Surgery"]}],"id":[{"id":"10.13039\/100013017","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","award":["Faculty Research Scholar"],"award-info":[{"award-number":["Faculty Research Scholar"]}],"id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["1018894"],"award-info":[{"award-number":["1018894"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:p> We present here a large animal platform for congestive hepatopathy, a disease growing in clinical prevalence due to the increasing number of Fontan-palliated patients. Further data are needed to develop a better clinical management strategy for this poorly characterized patient population. Previous reports of animal models to study this disease have mostly been in small animals with limited fidelity. We show that congestive hepatopathy can be replicated in a chronic, progressive pulmonary artery banding model in sheep. We also show that the banding strategy can be controlled to titrate the level of liver injury. To date, we do not know of any other large animal model that can achieve this level of control over disease phenotype and clinical relevance. <\/jats:p>","DOI":"10.1152\/japplphysiol.00473.2022","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T02:13:42Z","timestamp":1675995222000},"page":"840-845","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Pulmonary artery banding in sheep: a novel large animal model for congestive hepatopathy"],"prefix":"10.1152","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3523-6182","authenticated-orcid":false,"given":"Rei","family":"Ukita","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1834-5931","authenticated-orcid":false,"given":"Wei Kelly","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"},{"name":"Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7215-4346","authenticated-orcid":false,"given":"Jiancong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R.","family":"Talackine","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8672-5755","authenticated-orcid":false,"given":"Yatrik J.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean A.","family":"Francois","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Cardwell","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-0598","authenticated-orcid":false,"given":"Charles R.","family":"Flynn","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-5975","authenticated-orcid":false,"given":"Alexandra","family":"Shingina","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-7695","authenticated-orcid":false,"given":"Mary Kay","family":"Washington","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Quoc-Huy","family":"Trinh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-4484","authenticated-orcid":false,"given":"Matthew","family":"Bacchetta","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"},{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8785-7469","authenticated-orcid":false,"given":"Sophoclis P.","family":"Alexopoulos","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.045597"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.10.060"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30048"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001197"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001417"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3791\/62694"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.10.023"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.8634"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.79"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.8.7.863"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.00456"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c090014"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy620"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.07.006"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivz022"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000040"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27387"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.862330"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111891"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2018.05.027"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00473.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T17:31:53Z","timestamp":1679419913000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00473.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,1]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4,1]]}},"alternative-id":["10.1152\/japplphysiol.00473.2022"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00473.2022","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,1]]},"assertion":[{"value":"2022-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-06","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}