{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:14:06Z","timestamp":1792541646527,"version":"4.5.0"},"reference-count":250,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100006978","name":"University of California Berkeley | Center for Research and Education on Aging","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/100006978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG059715"],"award-info":[{"award-number":["R01AG059715"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:p> Lactate sensing and signaling is a relatively new and rapidly changing field. As a physiological signal lactate works both independently and in concert with other signals. Lactate operates via covalent binding and canonical signaling, redox change, and lactylation of DNA. Lactate can also serve as an element of feedback loops in cardiopulmonary regulation. From conception through aging lactate is not the only a myokine or exerkine, but it certainly deserves consideration as a physiological signal. <\/jats:p>","DOI":"10.1152\/japplphysiol.00497.2022","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T16:27:40Z","timestamp":1673540860000},"page":"529-548","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":171,"title":["Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism"],"prefix":"10.1152","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-1629","authenticated-orcid":false,"given":"George A.","family":"Brooks","sequence":"first","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam D.","family":"Osmond","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Arevalo","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin J.","family":"Duong","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey C.","family":"Curl","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana D.","family":"Moreno-Santillan","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7862-293X","authenticated-orcid":false,"given":"Robert G.","family":"Leija","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-70610-3_15"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0300258"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.008"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1113\/JP280955"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nature24057"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2172"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-0243-4"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2014.00027"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgw127"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.058701"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00022"},{"key":"B12","first-page":"2924","volume":"45","author":"Brooks GA","year":"1986","journal-title":"Fed Proc"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101454"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-017-3795-6"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00641-2"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1071\/r96102"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.07.020"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000927"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00408"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3203-6"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.648568"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4057"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.02.012"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.206"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/jfmk7040081"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.03.014"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.04.026"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0503-3"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.809485"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1678-1"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2021.09.009"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-8174com"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2014.03.004"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00214.2018"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80611-X"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2017.1406007"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.1213"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199708000-00010"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700381RR"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/biology11101541"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.11.035"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1661-18.2019"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322912111"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00035.2004"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-74911-2_9"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1674"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/nature15721"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.189241"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00614.2018"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120030"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094747"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00189.2019"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.03.004"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00218.2017"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901433R"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-018-0030-7"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110792"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01536"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32521-8"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.15.070146.001205"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3109\/00365517409114190"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77892-4"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/QJMED\/OS-16.62.135"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1933.106.3.689"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1983.244.1.E83"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1983.244.5.E505"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1979.236.1.C66"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1977.43.2.288"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1971.220.2.410"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198502000-00005"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113822"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.663560"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200090708"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1985.249.6.E595"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(67)90013-8"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.5.1684"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.4.1116"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-027306-5.50006-1"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(92)90148-4"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.382"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.2337\/diab.33.12.1188"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00365.2002"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1458"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1970.28.6.762"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(87)90296-7"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112019"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)66808-5"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1966.21.6.1767"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1113\/JP281371"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1007\/BF01712130"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1113\/JP279963"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)96046-1"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(81)90312-x"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12555"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019546"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.1.54"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01367.2003"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00402.2011"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00363.2006"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1007\/BF00585150"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00270.2021"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1080\/10715760000300431"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74465-2"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.6.1686"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.137331"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/nature14614"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1986.251.3.C395"},{"key":"B109","volume-title":"Exercise Physiology: Human Bioenergetics and Its Applications","author":"Brooks GA","year":"2019"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.56.4.831"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13813"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1042\/bse0420013"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00044.2005"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.008"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00724-0"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.63.6.1273"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X2022e11820"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.4.1748"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9493"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(64)90012-8"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1007\/BF00421101"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1080\/00913847.1983.11708485"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.786666"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002202"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.10.004"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00221.2011"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1038\/nature06244"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.031"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.063859"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.31.239"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29566"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90522-4"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1007\/BF02691358"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3419034"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1988.254.4.E407"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111551"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.3390\/nu6072632"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.2.295"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1038\/nature05484"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00081.2020"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.04.003"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2008.07.033"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2012.01.022"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00256.2020"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.3.663"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2040-10.2010"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.027128"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04828-5"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1126\/science.3375817"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600174"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3483"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3482"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10625"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1159\/000017324"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-191999"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-2236(02)02143-4"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00375"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.6.2253"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.275.5.E853"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.6.2097"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/s0305-0491(98)00025-x"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.90100.2007"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328358d59b"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0345"},{"key":"B165","first-page":"56","volume":"60","author":"Racker E","year":"1972","journal-title":"Am Sci"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00177.2010"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.034"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-017-0751-x"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36843"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2034"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.007724"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0653"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69741"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1353"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.178350"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90361-1"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1042\/bj3290321"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20091515"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.06.122"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.181412"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.07.034"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2006.07.005"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2012.08748.x"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.016"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1003"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.087411"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00594.2005"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.3.1129"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.5.1713"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00009.2004"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00476.2012"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1216"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.647559"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1820"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.3816\/CCC.2007.n.014"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.003"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.11.046"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64352-2"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.76.4.8473376"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.6353"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1158\/jcr.1925.148"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199907000-00011"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00753.2004"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev349"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.10.002"},{"key":"B206","author":"Hultman EA","year":"1967","journal-title":"Physiology of Muscular Exercise"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.278.2.E244"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01202.2012"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00032.2001"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00116.2001"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.4161\/isl.2.2.11025"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20141384"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1042\/BST0340811"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1086\/520960"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.12.12.5447"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37373"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.3390\/biology5040038"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1113\/EP085318"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00310.2021"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.276.5.E843"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.2018-0618"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1038\/nature13408"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2011.76.010678"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046571"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.04.001"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2009.10.009"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00499.2015"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.02.002"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.2.627"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-005-0085-5"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.4.1360"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.3.1175"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.04.018"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1113\/JP278931"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.278.4.E571"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00043.2013"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1530\/REP-16-0473"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac589"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1242\/dev.112.1.99"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.026"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500174200"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.79153"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.01.005"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99568-3"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.02.009"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.06.008"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20790-0"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht136"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.90217.2008"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-022-02775-y"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.023705"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00497.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T02:04:24Z","timestamp":1678932264000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00497.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":250,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3,1]]}},"alternative-id":["10.1152\/japplphysiol.00497.2022"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00497.2022","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,1]]},"assertion":[{"value":"2022-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}