{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:38:11Z","timestamp":1784306291496,"version":"3.55.0"},"reference-count":35,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p> Although systemic interleukin-6 (IL-6) level is elevated, hepatocellular function is impaired and liver injury occurs after trauma-hemorrhage (T-H), it remains unknown whether a causal relationship exists between elevated IL-6 levels and liver injury after T-H. We hypothesized that IL-6 is causative in the development of hepatic dysfunction and injury after T-H. To examine this, adult male Sprague-Dawley rats underwent a 5-cm midline laparotomy and were subjected to hemorrhagic shock (blood pressure = 35 mmHg for \u223c90 min), followed by resuscitation (Ringer lactate, 4 times the shed blood volume). At 2, 5, and 24 h thereafter, blood samples were collected and the liver isolated and perfused for 60 min. Portal inflow pressure was measured, and perfusate samples were collected to measure IL-6, alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels. A significant positive correlation between plasma levels of IL-6 and ALT and perfusate levels of IL-6 and LDH levels was observed. In a second series of experiments, rats were treated with immunoglobulin G (IgG) or antibodies against rat IL-6 (anti-IL-6) at the onset of resuscitation. At 5 h after resuscitation, anti-IL-6 treatment attenuated the T-H induced increases in plasma ALT and thromboxane B<jats:sub>2<\/jats:sub> (a thromboxane A<jats:sub>2<\/jats:sub> metabolite) levels, and bile flow was normalized to sham levels. Perfusion of livers from normal rats with IL-6 did not alter portal pressure; however, perfusion of a stable thromboxane A<jats:sub>2<\/jats:sub> analog dose dependently increased portal pressure. Thus IL-6 plays a significant role in the induction of hepatic dysfunction and liver injury after T-H that appears to be in part mediated by increased thromboxane A<jats:sub>2<\/jats:sub> levels. <\/jats:p>","DOI":"10.1152\/japplphysiol.00499.2004","type":"journal-article","created":{"date-parts":[[2004,8,6]],"date-time":"2004-08-06T20:24:11Z","timestamp":1091823851000},"page":"2184-2189","source":"Crossref","is-referenced-by-count":36,"title":["Insights into the role of interleukin-6 in the induction of hepatic injury after trauma-hemorrhagic shock"],"prefix":"10.1152","volume":"97","author":[{"given":"Balazs","family":"Toth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Schwacha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Loring W.","family":"Rue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirby I.","family":"Bland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irshad H.","family":"Chaudry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200014020-00001"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-199602000-00001"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.260.1.R167"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00724.2002"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.3.H1186"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)81208-5"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.3.306"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200209000-00007"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2003.00223.x"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900520"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1007\/s004020050421"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1998.275.3.L611"},{"key":"R13","unstructured":"Jarrar D, Chaudry IH, and Wang P. 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