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Because this transition cannot be readily addressed clinically, we modified a previously published model of whole-body CO<jats:sub>2<\/jats:sub> kinetics by adding respiratory control and renal bicarbonate kinetics. We enforced a pattern of 8 h of periodic breathing (sleep) and 16 h of regular ventilation (wakefulness) repeated for 20 days. Interventions included varying the initial awake respiratory CO<jats:sub>2<\/jats:sub> response and varying the rate of renal bicarbonate excretion within the physiological range. The results showed that acute hypercapnia during periodic breathing could transition into chronic sustained hypercapnia during wakefulness. Although acute hypercapnia could be attributed to periodic breathing alone, transition from acute to chronic hypercapnia required either slowing of renal bicarbonate kinetics, reduction of ventilatory CO<jats:sub>2<\/jats:sub> responsiveness, or both. Thus the model showed that the interaction between the time constant for bicarbonate excretion and respiratory control results in both failure of bicarbonate concentration to fully normalize before the next period of sleep and persistence of hypercapnia through blunting of ventilatory drive. These respiratory-renal interactions create a cumulative effect over subsequent periods of sleep that eventually results in a self-perpetuating state of chronic hypercapnia. <\/jats:p>","DOI":"10.1152\/japplphysiol.00502.2005","type":"journal-article","created":{"date-parts":[[2005,12,30]],"date-time":"2005-12-30T01:13:36Z","timestamp":1135905216000},"page":"1733-1741","source":"Crossref","is-referenced-by-count":91,"title":["Transition from acute to chronic hypercapnia in patients with periodic breathing: predictions from a computer model"],"prefix":"10.1152","volume":"100","author":[{"given":"Robert G.","family":"Norman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta M.","family":"Goldring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M.","family":"Clain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno W.","family":"Oppenheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan N.","family":"Charney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Rapoport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth I.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200203-212OC"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.4.1231"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01082.2001"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.1.257"},{"key":"R5","unstructured":"Berthon-Jones M and Sullivan CE. 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