{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:29:54Z","timestamp":1785407394285,"version":"3.56.0"},"reference-count":72,"publisher":"American Physiological Society","issue":"5","funder":[{"name":"Grant Agency of Charles University","award":["GAUK 119524"],"award-info":[{"award-number":["GAUK 119524"]}]},{"name":"Ministry of Education, Youth and Sport of the Czech Republic CR","award":["LM2023050 Czech-BioImaging"],"award-info":[{"award-number":["LM2023050 Czech-BioImaging"]}]},{"name":"Charles University Institutional Research Fund","award":["SVV-260790"],"award-info":[{"award-number":["SVV-260790"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>Moderate cold acclimation (CA) gradually reduces total reperfusion PVCs and tachyarrhythmia duration in rat myocardium, detectable after 5 wk and lost after a 2-wk recovery. Reduced n-6\/n-3 PUFA ratio, protective Cx43 and UCP1 distribution, and increased GPX4 expression supports the antiarrhythmic effect elicited by CA. Mitochondrial antioxidants SOD2 and TXNRD2 are upregulated after just 1 day of exposure. The brown adipose tissue-to-body weight ratio increases during CA, and mitochondrial density exhibits an independent pattern of change.<\/jats:p>","DOI":"10.1152\/japplphysiol.00509.2025","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T01:01:14Z","timestamp":1758675674000},"page":"1156-1168","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Long-term exposure to moderate cold reduces incidence of reperfusion tachyarrhythmias in rats"],"prefix":"10.1152","volume":"139","author":[{"given":"Pavel","family":"Vebr","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"publisher"}],"name":"Charles University","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8175-2604","authenticated-orcid":false,"given":"Frantisek","family":"Galatik","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"publisher"}],"name":"Charles University","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Marvanova","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"publisher"}],"name":"Charles University","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6277-2634","authenticated-orcid":false,"given":"Barbara","family":"Elsnicova","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"publisher"}],"name":"Charles University","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3699-5575","authenticated-orcid":false,"given":"Daniela","family":"Hornikova","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"publisher"}],"name":"Charles University","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Vecka","sequence":"additional","affiliation":[{"name":"Charles University and General Teaching Hospital","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2193-6383","authenticated-orcid":false,"given":"Sarka","family":"Spinov\u00e1","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"publisher"}],"name":"Charles University","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Novakova","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"publisher"}],"name":"Charles University","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6939-7136","authenticated-orcid":false,"given":"Jitka M.","family":"Zurmanova","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"publisher"}],"name":"Charles University","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/252310a0"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1210\/EN.2005-1216"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.050989"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021352"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e328337a81f"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2021.1903145"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13348"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/JAPPLPHYSIOL.00511.2019"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-44205-4"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/JAPPLPHYSIOL.00756.2020"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.229864"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2005.01372.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19851"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(83)90198-4"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(88)80027-0"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.12.013"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/S12915-023-01514-4\/FIGURES\/7"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2018.04.012"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2017.00137\/BIBTEX"},{"key":"B20","first-page":"823","volume":"232","author":"Hlav\u00e1\u010dkov\u00e1 M","year":"2007","journal-title":"Exp Biol Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2018.00789"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-005-0786-z"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.94.7.1774"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.09.010"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04188-4"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/415096a"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020322"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2022.184084"},{"key":"B29","first-page":"63","volume":"60","author":"Dlugosova K","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-011-0247-5"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1177\/174182679400100112"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512001584"},{"key":"B33","first-page":"2004","volume":"51","author":"Saito H","year":"1993","journal-title":"Nihon Rinsho"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(18)64849-5"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014889115509"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(02)00396-3"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1993.tb03313.x"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/0160-5402(82)90029-8"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000014682.14181.F2"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/NU9111191"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/BIOMEDICINES8090306"},{"key":"B43","first-page":"717","volume":"61","author":"Bacova B","year":"2010","journal-title":"J Physiol Pharmacol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0B013E328362215D"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2007.07.001"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr209"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306276"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.202213150"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2021.03.008"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124200"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.3.890"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.116426"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00689.2006"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.131391"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00002.2021"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2018-000904"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxaa256"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509389242"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108838"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1042\/BST20210579"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/BF02534453"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021715"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.092700"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2018.05.019"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00592.2012"},{"key":"B66","first-page":"3360","volume":"9","author":"Du Q","year":"2017","journal-title":"Am J Transl Res"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-022-04656-1"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.05.014"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac134"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2015.07.007"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13020143"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00203"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00509.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:34:54Z","timestamp":1763750094000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00509.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11,1]]}},"alternative-id":["10.1152\/japplphysiol.00509.2025"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00509.2025","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]},"assertion":[{"value":"2025-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}