{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T08:12:30Z","timestamp":1776759150477,"version":"3.51.2"},"reference-count":42,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p> Chronic hyperoxia during the first 1\u20134 postnatal weeks attenuates the hypoxic ventilatory response (HVR) subsequently measured in adult rats. Rather than focusing on this long-lasting plasticity, the present study considered the influence of hyperoxia on respiratory control during the neonatal period. Sprague-Dawley rats were born and raised in 60% O<jats:sub>2<\/jats:sub> until studied at postnatal ages (P) of 4, 6\u20137, or 13\u201314 days. Ventilation and metabolism were measured in normoxia (21% O<jats:sub>2<\/jats:sub>) and acute hypoxia (12% O<jats:sub>2<\/jats:sub>) using head-body plethysmography and respirometry, respectively. Compared with age-matched rats raised in room air, the major findings were 1) diminished pulmonary ventilation and metabolic O<jats:sub>2<\/jats:sub> consumption in normoxia at P4 and P6\u20137; 2) decreased breathing stability during normoxia; 3) attenuation of the early phase of the HVR at P6\u20137 and P13\u201314; and 4) a sustained increase in ventilation during hypoxia (vs. the normal biphasic HVR) at all ages studied. Attenuation of the early HVR likely reflects progressive impairment of peripheral arterial chemoreceptors while expression of a sustained HVR in neonates before P7 suggests that hyperoxia also induces plasticity within the central nervous system. Together, these results suggest a complex interaction between inhibitory and excitatory effects of hyperoxia on the developing respiratory control system. <\/jats:p>","DOI":"10.1152\/japplphysiol.00510.2010","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T22:37:39Z","timestamp":1277419059000},"page":"796-803","source":"Crossref","is-referenced-by-count":42,"title":["Chronic hyperoxia alters the early and late phases of the hypoxic ventilatory response in neonatal rats"],"prefix":"10.1152","volume":"109","author":[{"given":"Ryan W.","family":"Bavis","sequence":"first","affiliation":[{"name":"Department of Biology, Bates College, Lewiston, Maine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen M.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Biology, Bates College, Lewiston, Maine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin 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