{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:40:32Z","timestamp":1778172032147,"version":"3.51.4"},"reference-count":19,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:p> The advent of artificial ventilation was largely sparked by the popular belief that drowning and other causes of asphyxia could induce death-like states known as suspended animation. While the mystical nature of such states befuddled some physicians into the early 1900s, an English medical student by the name of Edmund Goodwyn (1756\u20131829) published a thesis in 1786, which demonstrated that suspended animation was simply the physical manifestation of extreme hypoxia. Goodwyn\u02bcs work advanced one of the earliest arguments in favor of artificial ventilation for the treatment of asphyxia over alternative resuscitation measures like heat and exsanguination. In addition, Goodwyn\u2019s remarkable dissertation contains the first account of a reflex known as diving bradycardia, and possibly the first vehement refutation of claims by his contemporaries that pulmonary circulation stopped during exhalation. While miscellaneous aspects of his thesis have occasionally been mentioned by a few medical historians, the overall visionary nature of his work has yet to be recognized. This article attempts to accomplish this goal and to provide a first biographical glimpse of a man whose scientific career appears to have ended prematurely, perhaps because of his profound aversion to controversy. <\/jats:p>","DOI":"10.1152\/japplphysiol.00515.2018","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T11:35:17Z","timestamp":1533209717000},"page":"1128-1130","source":"Crossref","is-referenced-by-count":2,"title":["<i>The Connection of Life with Respiration:<\/i> Edmund Goodwyn\u2019s unexplored treasure of cardiopulmonary physiology"],"prefix":"10.1152","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7987-4004","authenticated-orcid":false,"given":"Jose L.","family":"Vega","sequence":"first","affiliation":[{"name":"Department of Neurosciences and Stroke, Novant Health, Forsyth Medical Center, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","first-page":"1313","volume":"2","author":"Anonymous","year":"1911","journal-title":"BMJ"},{"key":"B2","volume-title":"Recherches Physiologiques sur la Vie et la Mort","author":"Bichat X","year":"1800"},{"key":"B3","volume-title":"The Memoirs of Chateaubriand","author":"Chateaubriand FR","year":"1902"},{"key":"B4","volume-title":"Matriculation Albums","author":"Edinburgh University","year":"1762"},{"key":"B5","first-page":"74","volume":"34","author":"Goodwyn E","year":"1830","journal-title":"Edinburgh Med Surg J"},{"key":"B6","volume-title":"The Connexion of Life with Respiration; or, an Experimental Inquiry into the Effects of Submersion, Strangulation, and Several Kinds of Noxious Airs, on Living Animals: with an Account of the Nature of the Disease They Produce; Its Distinction from Death Itself; and the Most Effectual Means of Cure","author":"Goodwyn E","year":"1788"},{"key":"B7","volume-title":"Dissertatio Medica de Morteque Submersorum Investigandis","author":"Goodwyn E","year":"1786"},{"key":"B8","volume-title":"Edmund Goodwyn (1756\u20131829)","author":"Goodwyn P","year":"2000"},{"key":"B9","volume-title":"The History, Topography, and Antiquities of Framlingham and Saxsted","author":"Green R","year":"1834"},{"key":"B10","volume-title":"An Essay on the Recovery of the Apparently Dead","author":"Kite C","year":"1788"},{"key":"B11","volume-title":"Tractatus de Corde. Item de Motu & Colore Sanguinis et Chyli in Eum Transitu","author":"Lower R","year":"1669"},{"key":"B12","volume-title":"Chemical Experiments and Opinions Extracted from a Work Published in the Last Century","author":"Mayow J","year":"1790"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-2707-0_2"},{"key":"B14","first-page":"80","volume-title":"European Traditions in the Study of Religion in Africa","author":"Platvoet JG","year":"2004"},{"key":"B15","volume-title":"Dictionary of National Biography","author":"Rigg JM","year":"1890"},{"key":"B16","volume-title":"Premature Burial and How It May Be Prevented","author":"Tebb W","year":"1905"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00221.2017"},{"key":"B18","volume-title":"Eighteen Century Medics: Subscriptions, Licenses, Apprenticeships","author":"Wallis PJ","year":"1985"},{"key":"B19","volume-title":"The Uncertainty of the Signs of Death and the Danger of Precipitate Interments and Dissections, Demonstrated","author":"Winslow JB","year":"1746"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00515.2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T23:41:41Z","timestamp":1567986101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00515.2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,1]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10,1]]}},"alternative-id":["10.1152\/japplphysiol.00515.2018"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00515.2018","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,1]]}}}