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This analysis indicates that during PB, when by necessity LG is &gt;1, replacement of the inspired gas with one of reduced Po<jats:sub>2<\/jats:sub>lowers LG; if we made inspired Po<jats:sub>2<\/jats:sub>approximate alveolar Po<jats:sub>2<\/jats:sub>, we predict that LG would be approximately zero and breathing would promptly stabilize. In six lambs, we switched the inspired gas from an inspiratory oxygen fraction of 0.4 to one of 0.12 during an epoch of PB; PB was immediately suppressed, supporting the view that the peripheral chemoreceptors play a pivotal role in the genesis and control of unstable breathing in the lamb. In the six lambs in which we administered hypercapnic gas during PB, breathing instability was also suppressed, but only after a considerable time lag, indicating the CO<jats:sub>2<\/jats:sub>effect is likely to have been mediated through the central chemoreceptors. When we simulated both interventions in a published model of the adult respiratory controller, PB was immediately suppressed by CO<jats:sub>2<\/jats:sub>inhalation and exacerbated by inhalation of hypoxic gas. These fundamentally different responses in lambs and adult humans demonstrate that PB has differing underlying mechanisms in the two species.<\/jats:p>","DOI":"10.1152\/japplphysiol.00532.2004","type":"journal-article","created":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:13:24Z","timestamp":1097280804000},"page":"437-446","source":"Crossref","is-referenced-by-count":14,"title":["Impact of changes in inspired oxygen and carbon dioxide on respiratory instability in the lamb"],"prefix":"10.1152","volume":"98","author":[{"given":"Malcolm H.","family":"Wilkinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kah-Ling","family":"Sia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Skuza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vojta","family":"Brodecky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1053\/sper.2001.23199"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12020414"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199907000-00009"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Berger PJ, Skuza EM, Brodecky V, Cranage SM, Adamson TM, and Wilkinson MH.Unusual respiratory response to oxygen in an infant with repetitive cyanotic episodes.Am J Respir Crit Care Med161: 2107\u20132111, 2001.","DOI":"10.1164\/ajrccm.161.6.9908106"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.5.1779"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014906"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1956.tb01343.x"},{"key":"R8","unstructured":"Blanchard PWand Aranda JV.Pharmacotherapy of respiratory control disorders. 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