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ICSI induced moderate hypothermia (defined as 32\u201334\u00b0C) in the internal carotid artery (ICA) territory within 5 min. Incorporation of the complete CoW resulted in a similar level of hypothermia in the ICA territory. In addition, the anterior communicating artery and ipsilateral posterior communicating artery distributed cool blood to the contralateral anterior and ipsilateral posterior territories, respectively, imparting mild hypothermia (35 and 35.5\u00b0C respectively). The mA1 and fP1 variants allowed for sufficient cooling of the middle cerebral territory (30\u201332\u00b0C). The simulations suggest that ICSI is feasible and may be the fastest method of inducing hypothermia. Moreover, the effect of convective heat transfer via the complete CoW and its variants underlies the important role of CoW anatomy in intracerebral temperature distributions during SBC. <\/jats:p>","DOI":"10.1152\/japplphysiol.00542.2007","type":"journal-article","created":{"date-parts":[[2007,8,30]],"date-time":"2007-08-30T20:58:14Z","timestamp":1188507494000},"page":"1837-1847","source":"Crossref","is-referenced-by-count":20,"title":["Integration of jugular venous return and circle of Willis in a theoretical human model of selective brain cooling"],"prefix":"10.1152","volume":"103","author":[{"given":"Matthew A.","family":"Neimark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelos-Aristeidis","family":"Konstas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F.","family":"Laine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Pile-Spellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000218166.54150.0a"},{"key":"R2","unstructured":"Baish JW. 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