{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:09:11Z","timestamp":1773421751149,"version":"3.50.1"},"reference-count":38,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p> The aims of this study were to determine 1) whether ventilatory adaptation occurred over a 5-day exposure to a constant elevation in end-tidal Pco<jats:sub>2<\/jats:sub> and 2) whether such an exposure altered the sensitivity of the chemoreflexes to acute hypoxia and hypercapnia. Ten healthy human subjects were studied over a period of 13 days. Their ventilation, chemoreflex sensitivities, and acid-base status were measured daily before, during, and after 5 days of elevated end-tidal Pco<jats:sub>2<\/jats:sub> at 8 Torr above normal. There was no major adaptation of ventilation during the 5 days of hypercapnic exposure. There was an increase in ventilatory chemosensitivity to acute hypoxia (from 1.35 \u00b1 0.08 to 1.70 \u00b1 0.07 l\/min\/%; P &lt; 0.01) but no change in ventilatory chemosensitivity to acute hypercapnia. There was a degree of compensatory metabolic alkalosis. The results do not support the hypothesis that the ventilatory adaptation to chronic hypercapnia would be much greater with constant elevation of alveolar Pco<jats:sub>2<\/jats:sub> than with constant elevation of inspired Pco<jats:sub>2<\/jats:sub>, as has been used in previous studies and in which the feedback loop between ventilation and alveolar Pco<jats:sub>2<\/jats:sub> is left intact. <\/jats:p>","DOI":"10.1152\/japplphysiol.00548.2003","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:47:13Z","timestamp":1425415633000},"page":"1947-1954","source":"Crossref","is-referenced-by-count":17,"title":["Respiratory effects in humans of a 5-day elevation of end-tidal PCO2 by 8 Torr"],"prefix":"10.1152","volume":"95","author":[{"given":"Alexi","family":"Crosby","sequence":"first","affiliation":[{"name":"University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick P.","family":"Talbot","sequence":"additional","affiliation":[{"name":"University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George M.","family":"Balanos","sequence":"additional","affiliation":[{"name":"University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Donoghue","sequence":"additional","affiliation":[{"name":"University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzieh","family":"Fatemian","sequence":"additional","affiliation":[{"name":"University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Robbins","sequence":"additional","affiliation":[{"name":"University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196901162800301"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.46.4.843"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(86)90010-1"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.3.1011"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196501072720102"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196901162800302"},{"key":"REF7","unstructured":"Burnett BR, Christiansen TF, Durst RA, Evenson R, Fallon K, Komjathy ZL, Ladenson JH, Moran RF, Pulwer E, Weisberg HF, and Zee D. 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