{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:18:37Z","timestamp":1774567117773,"version":"3.50.1"},"reference-count":37,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2003,1,1]]},"abstract":"<jats:p>To determine whether drying and hypertonicity of the airway surface fluid (ASF) are involved in thermally induced asthma, nine subjects performed isocapnic hyperventilation (HV) (minute ventilation 62.2 \u00b1 8.3 l\/min) of frigid air (\u22128.9 \u00b1 3.3\u00b0C) while periciliary fluid was collected endoscopically from the trachea. Osmolality was measured by freezing-point depression. The baseline 1-s forced expiratory volume was 73 \u00b1 4% of predicted and fell 26.4% 10 min postchallenge ( P &gt; 0.0001). The volume of ASF collected was 11.0 \u00b1 2.2 \u03bcl at rest and remained constant during and after HV as the airways narrowed (HV 10.6 \u00b1 1.9, recovery 6.5 \u00b1 1.7 \u03bcl; P = 0.18). The osmolality also remained stable throughout (rest 336 \u00b1 16, HV 339 \u00b1 16, and recovery 352 \u00b1 19 mosmol\/kgH<jats:sub>2<\/jats:sub>O, P = 0.76). These data demonstrate that airway desiccation and hypertonicity of the ASF do not develop during hyperpnea in asthma; therefore, other mechanisms must cause exercise- and hyperventilation-induced airflow limitation.<\/jats:p>","DOI":"10.1152\/japplphysiol.00551.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:43:12Z","timestamp":1425415392000},"page":"227-233","source":"Crossref","is-referenced-by-count":20,"title":["Desiccation and hypertonicity of the airway surface fluid and thermally induced asthma"],"prefix":"10.1152","volume":"94","author":[{"given":"Chakradhar","family":"Kotaru","sequence":"first","affiliation":[{"name":"General Clinical Research Center of Case Western Reserve University School of Medicine and Division of Pulmonary and Critical Care Medicine and Department of Medicine of University Hospitals of Cleveland, Cleveland 44106; and MetroHealth Medical Center, Cleveland, Ohio 44109-1998"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana B.","family":"Hejal","sequence":"additional","affiliation":[{"name":"General Clinical Research Center of Case Western Reserve University School of Medicine and Division of Pulmonary and Critical Care Medicine and Department of Medicine of University Hospitals of Cleveland, Cleveland 44106; and MetroHealth Medical Center, Cleveland, Ohio 44109-1998"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Finigan","sequence":"additional","affiliation":[{"name":"General Clinical Research Center of Case Western Reserve University School of Medicine and Division of Pulmonary and Critical Care Medicine and Department of Medicine of University Hospitals of Cleveland, Cleveland 44106; and MetroHealth Medical Center, Cleveland, Ohio 44109-1998"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert J.","family":"Coreno","sequence":"additional","affiliation":[{"name":"General Clinical Research Center of Case Western Reserve University School of Medicine and Division of Pulmonary and Critical Care Medicine and Department of Medicine of University Hospitals of Cleveland, Cleveland 44106; and MetroHealth Medical Center, Cleveland, Ohio 44109-1998"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"Skowronski","sequence":"additional","affiliation":[{"name":"General Clinical Research Center of Case Western Reserve University School of Medicine and Division of Pulmonary and Critical Care Medicine and Department of Medicine of University Hospitals of Cleveland, Cleveland 44106; and MetroHealth Medical Center, Cleveland, Ohio 44109-1998"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Brianas","sequence":"additional","affiliation":[{"name":"General Clinical Research Center of Case Western Reserve University School of Medicine and Division of Pulmonary and Critical Care Medicine and Department of Medicine of University Hospitals of Cleveland, Cleveland 44106; and MetroHealth Medical Center, Cleveland, Ohio 44109-1998"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"E. 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