{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T21:22:36Z","timestamp":1783286556092,"version":"3.54.6"},"reference-count":72,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)","doi-asserted-by":"publisher","award":["R01 DC014358"],"award-info":[{"award-number":["R01 DC014358"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)","doi-asserted-by":"publisher","award":["R21 DC016135"],"award-info":[{"award-number":["R21 DC016135"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)","doi-asserted-by":"publisher","award":["F32 DC014399"],"award-info":[{"award-number":["F32 DC014399"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:p>Neuromuscular pathology is found in the larynx and pharynx in humans with Parkinson disease (PD); however, it is unknown when this pathology emerges. We hypothesized that pathology occurs in early (premanifest) stages. To address this, we used the Pink1\u2212\/\u2212 rat model of PD, which shows age-dependent dopaminergic neuron loss, locomotor deficits, and deficits related to laryngeal function. We report findings in the thyroarytenoid muscle (TA) in Pink1\u2212\/\u2212 rats compared with wild-type (WT) control rats at 4 and 6 mo of age. TAs were analyzed for force production, myosin heavy chain isoform (MyHC), centrally nucleated myofibers, neural cell adhesion molecule, myofiber size, and muscle section size. Compared with WT, Pink1\u2212\/\u2212 TA had reductions in force levels at 1-Hz stimulation and 20-Hz stimulation, increases in relative levels of MyHC 2L, increases in incidence of centrally nucleated myofibers in the external division of the TA, and reductions in myofiber size of the vocalis division of the TA at 6 mo of age. Alterations of laryngeal muscle biology occur in a rat model of premanifest PD. Although these alterations are statistically significant, their functional significance remains to be determined.<\/jats:p><jats:p>NEW &amp; NOTEWORTHY Pathology of peripheral nerves and muscle has been reported in the larynx and pharynx of humans diagnosed with Parkinson disease (PD); however, it is unknown whether differences of laryngeal muscle occur at premanifest stages. This study examined the thyroarytenoid muscles of the Pink1\u2212\/\u2212 rat model of PD for differences of muscle biology compared with control rats. Thyroarytenoid muscles of Pink1\u2212\/\u2212 rats at premanifest stages show differences in multiple measures of muscle biology.<\/jats:p>","DOI":"10.1152\/japplphysiol.00557.2018","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T20:43:06Z","timestamp":1551991386000},"page":"1326-1334","source":"Crossref","is-referenced-by-count":14,"title":["Laryngeal muscle biology in the<i>Pink1\u2212\/\u2212<\/i>rat model of Parkinson disease"],"prefix":"10.1152","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9799-5862","authenticated-orcid":false,"given":"Tiffany J.","family":"Glass","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Wisconsin, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A.","family":"Kelm-Nelson","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Wisconsin, Madison, 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